2型糖尿病患者慢性并发症的临床风险因素及与骨密度、1,25-二羟维生素D3的相关性  

Clinical risk factors for chronic complications in patients with type 2diabetes and their correlation with bone mineral densityand 1,25-dihydroxyvitamin D3

作　　者：罗云霞 刘利 尹凡 龙青 LUO Yunxia;LIU Li;YIN Fan;LONG Qing(Department of General Medicine,Sichuan University West China Guang′an Hospital,Guang′an,Sichuang 638000,China;Department of Respiratory Medicine,Sichuan University West China Guang′an Hospital,Guang′an,Sichuang 638000,China;Department of Gastroenterology,Sichuan University West China Guang′an Hospital,Guang′an,Sichuang 638000,China)

机构地区：[1]四川大学华西广安医院全科医学科,四川广安638000 [2]四川大学华西广安医院呼吸科,四川广安638000 [3]四川大学华西广安医院消化内科,四川广安638000

出　　处：《公共卫生与预防医学》2024年第3期99-102,共4页Journal of Public Health and Preventive Medicine

摘　　要：目的分析2型糖尿病患者慢性并发症的临床风险因素及其与骨密度、1,25-二羟维生素D3的相关性。方法选取326例2型糖尿病患者作为研究对象,根据有无慢性并发症分为并发症组、无并发症组,分析2型糖尿病患者发生慢性并发症的独立相关因素,采用Spearman秩相关分析评估骨密度、1,25-二羟维生素D3与慢性并发症之间的相关性。结果326例2型糖尿病患者中,202例发生慢性并发症,发生率为61.96%,其中心血管病71例,神经病变59例,肾脏病变33例,视网膜病变28例。并发症组与无并发症组糖尿病病程、空腹血糖、收缩压、糖化血红蛋白、三酰甘油、低密度脂蛋白胆固醇、血肌酐、骨密度、1,25-二羟维生素D3差异均有统计学意义(P<0.05)。logistic多因素回归分析显示,糖尿病病程、收缩压、糖化血红蛋白、低密度脂蛋白胆固醇、血肌酐、骨密度、1,25-二羟维生素D3均为2型糖尿病患者发生慢性并发症的独立相关因素(P<0.05)。Spearman相关性分析显示,骨密度、1,25-二羟维生素D3水平均与慢性并发症呈负相关(P<0.05)。结论2型糖尿病患者骨密度、1,25-二羟维生素D3与慢性并发症密切相关。Objective To analyze the clinical risk factors for chronic complications in patients with type 2 diabetes and their correlation with bone mineral density and 1,25-dihydroxyvitamin D3.Methods A total of 163 patients with type 2 diabetes mellitus were selected as research subjects and were divided into complication group and non-complication group according to the presence or absence of chronic complications.The independent related factors for chronic complications in patients with type 2 diabetes mellitus were analyzed.Spearman rank correlation analysis was used to evaluate the correlation between bone mineral density,1,25-dihydroxyvitamin D3 and chronic complications.Results Among the 326 patients with type 2 diabetes mellitus,202 developed chronic complications(61.96%),including 71 cases of cardiovascular disease,59 cases of neuropathy,33 cases of renal lesion,and 28 cases of retinopathy.There were statistically significant differences in the duration of diabetes mellitus,fasting blood glucose,systolic blood pressure,glycosylated hemoglobin,triglyceride,low density lipoprotein cholesterol,serum creatinine,bone mineral density,and 1,25-dihydroxyvitamin D3 between the complication group and the non-complication group(P<0.05).Logistic multivariate regression analysis showed that the duration of diabetes mellitus,systolic blood pressure,glycosylated hemoglobin,ow density lipoprotein cholesterol,serum creatinine,bone mineral density,and 1,25-dihydroxyvitamin D3 were all independent related factors for the occurrence of chronic complications in patients with type 2 diabetes mellitus(P<0.05).Spearman correlation analysis showed that bone mineral density and 1,25-dihydroxyvitamin D3 were negatively correlated with chronic complications(P<0.05).Conclusion Bone mineral density and 1,25-dihydroxyvitamin D3 in patients with type 2 diabetes mellitus are closely related to chronic complications.

关 键 词：2型糖尿病 慢性并发症 骨密度 1 25-二羟维生素D3 

分 类 号：R181[医药卫生—流行病学]