Nod样受体蛋白3在急性胰腺炎中的作用机制研究进展  

Research progress in the mechanism of NOD-like receptor protein 3 in acute pancreatitis

作　　者：那千博 冯佳明 卫江鹏 杨斌 王士祺 赵青川 余鹏飞 Na Qianbo;Feng Jiaming;Wei Jiangpeng;Yang Bin;Wang Shiqi;Zhao Qingchuan;Yu Pengfei(Department of Gastrointestinal Surgery,the First Affiliated Hospital of Air Force Medical University,Xi'an 710032,China;17th Team of the 5th Battalion,Basic Medical College,Air Force Military University,Xi'an 710032,China;8th Team of the 2nd Battalion,Basic Medical College,Air Force Military University,Xi'an 710032,China)

机构地区：[1]中国人民解放军空军军医大学第一附属医院胃肠外科,西安710032 [2]中国人民解放军空军军医大学基础医学院五大队十七队,西安710032 [3]中国人民解放军空军军医大学基础医学院二大队八队,西安710032

出　　处：《中华实验外科杂志》2024年第3期652-656,共5页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金青年项目(82100680、82103664)。

摘　　要：急性胰腺炎是一种有潜在致命风险的消化道疾病,预后主要取决于胰腺或胰周坏死的继发感染和器官衰竭的情况。大约10%~20%的急性胰腺炎患者会进展成为重症急性胰腺炎,病情险恶、并发症多、病死率较高。Nod样受体蛋白3(NLRP3)炎性小体的发现丰富了我们对多种炎症性疾病发病机制的认识。NLRP3炎性小体是一种蛋白复合体,是炎症的主要驱动因素。越来越多研究表明,NLRP3炎性小体在急性胰腺炎中的无菌性炎性反应中发挥至关重要的作用。但NLRP3炎症小体激活的具体调控机制尚不清楚。因此,我们对NLRP3炎症小体在急性胰腺炎中的作用机制研究进展进行了全面综述。Acute pancreatitis is a digestive disease with potentially fatal risk,and the prognosis mainly depends mainly on secondary infection and organ failure with pancreatic or peripancreatic necrosis.About 10%to 20%of patients with acute pancreatitis will progress to severe acute pancreatitis,with dangerous conditions,many complications,and a high case fatality rate.The discovery of the NOD-like receptor protein 3(NLRP3)inflammasome has enriched our understanding of the pathogenesis of multiple inflammatory diseases.The NLRP 3 inflammasome is a protein complex that is a major driver of inflammation.More and more studies have shown that the NLRP 3 inflammasome plays a crucial role in the aseptic inflammatory response in acute pancreatitis.However,the specific regulatory mechanism of NLRP3 inflammasome activation remains unclear.Therefore,we conducted a comprehensive review of the mechanism of the NLRP 3 inflammasome on acute pancreatitis.

关 键 词：NLRP3炎性小体 胰腺炎 免疫系统 白细胞介素 损伤相关分子模式 全身炎性反应综合征 

分 类 号：R576[医药卫生—消化系统]