小儿肺热咳喘颗粒辅助治疗小儿急性支气管肺炎痰热壅肺证56例临床观察  

Clinical observation on 56 cases of acute bronchopneumonia with phlegm heat obstruction in the lungs treated with Xiao'er Feire Kechuan Granules(小儿肺热咳喘颗粒)as an adjuvant therapy

作　　者：王骥超 许超敏 陈燕娜 朱妍璐 WANG Jichao;XU Chaomin;CHEN Yanna;ZHU Yanlu(Department of Pediatrics,the First Affiliated Hospital of Ningbo University,Ningbo,Zhejiang,315020,China;Department of Image Diagnoses,the First Affiliated Hospital of Ningbo University,Ningbo,Zhejiang,315020,China)

机构地区：[1]宁波大学附属第一医院儿内科,浙江宁波315020 [2]宁波大学附属第一医院影像科,浙江宁波315020

出　　处：《中医儿科杂志》2024年第2期48-52,共5页Journal of Pediatrics of Traditional Chinese Medicine

基　　金：浙江省医学会临床科研资金资助项目(2020ZYC-A103)。

摘　　要：目的观察小儿肺热咳喘颗粒辅助治疗小儿急性支气管肺炎痰热壅肺证的临床疗效及对患儿机体炎症反应、免疫功能的影响。方法选取2020年6月至2022年6月宁波大学附属第一医院(原宁波大学医学院附属医院)儿内科住院部收治的急性支气管肺炎痰热壅肺证患儿112例,采用随机数字表法分为治疗组和对照组,各56例。2组均给予吸氧、降温、止咳化痰、抗感染等常规对症治疗,对照组在上述对症治疗的基础上给予雾化吸入,治疗组在对照组治疗方法的基础上联合小儿肺热咳喘颗粒口服,2组均以7 d为1个疗程,治疗1个疗程后统计临床疗效。结果治疗组总有效率为96.43%(54/56),显著高于对照组的85.71%(47/56),2组比较,差异有统计学意义(P<0.05)。治疗组咳嗽咳痰、肺部啰音消失时间及体温恢复正常时间均早于对照组,2组比较,差异均有统计学意义(P<0.05)。治疗前2组血清炎症因子白细胞介素-8(IL-8)、C-反应蛋白(CRP)和肿瘤坏死因子-α(TNF-α)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组IL-8、CRP、TNF-α水平均显著下降,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。治疗前2组血清免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组IgA、IgG、IgM水平均显著升高,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组升高更显著(P<0.05)。结论小儿肺热咳喘颗粒辅助治疗小儿急性支气管肺炎痰热壅肺证,能明显改善患儿的临床症状、体征,减轻机体炎症反应,提高免疫功能,疗效显著,值得临床推广应用。Objective To observe the clinical efficacy of Xiao'er Feire Kechuan Granules(小儿肺热咳喘颗粒)as an adjuvant therapy for acute bronchopneumonia with phlegm heat obstruction in the lungs in children,and its impact on the inflammatory response and immune function of the children's body.Methods A total of 112 pediatric patients with acute bronchopneumonia with phlegm heat obstruction in the lungs admitted to the Department of Pediatrics,the First Affiliated Hospital of Ningbo University from June 2020 to June 2022 were selected.They were randomly divided into a treatment group and a control group using a random number table method,with 56 cases in each group.Both groups were given routine symptomatic treatments such as oxygen inhalation,cooling,cough relieving and phlegm resolving,and anti infection.The control group was given nebulized inhalation on the basis of the symptomatic treatment mentioned above.The treatment group was given oral administration of Xiao'er Feire Kechuan Granules in combination with the control group's treatment method.The two groups were treated for 7 days per course,and the clinical efficacy was calculated after one course of treatment.Results The total effective rate of the treatment group was 96.43%(54/56),significantly higher than the control group's 85.71%(47/56).The difference between the two groups was statistically significant(P<0.05).The disappearance time of cough and sputum,lung rales,and normal body temperature in the treatment group were all earlier than those in the control group.Comparison of the levels of inflammatory factors serum interleukin-8(IL-8),C-reactive protein(CRP)and tumour necrosis factor-α(TNF-α)in the 2 groups before treatment,the difference was not statistically significant(P>0.05)and was comparable;after treatment,the levels of serum IL-8,CRP and TNF-αin the 2 groups decreased significantly,and the difference was statistically significant when compared with the same group before treatment(P<0.05),and the decrease was more significant in the treatmen

关 键 词：小儿 急性支气管肺炎 痰热壅肺证 小儿肺热咳喘颗粒 炎症因子 免疫功能 临床观察 

分 类 号：R256.1[医药卫生—中医内科学]