福州市1073例HIV/AIDS患者抗病毒治疗效果及耐药情况分析  

Analysis on effect of antiretroviral therapy and drug resistance for 1073 AIDS/HIV patients in Fuzhou city

作　　者：陈玲玲 姚栩[1] 石蕾[1] 陈艳[1] 卢园[1] CHEN Ling-ling;YAO Xu;SHI Lei;CHEN Yan;LU Yuan(Laboratory Department,Fuzhou City Center for Disease Control and Prevention,Fujian 350004,China)

机构地区：[1]福州市疾病预防控制中心检验科,福建350004

出　　处：《预防医学论坛》2024年第1期52-55,76,共5页Preventive Medicine Tribune

摘　　要：目的探讨福州市1073例HIV/AIDS患者抗病毒治疗的效果和耐药情况,为进一步完善艾滋病抗病毒治疗提供依据。方法采用回顾性调查方法,收集2019年1月-2020年12月在福州市接受抗病毒治疗的1073例HIV/AIDS患者的资料,评价抗病毒治疗后患者的CD4^(+)T淋巴细胞计数、病毒载量以及耐药情况,评价抗病毒治疗效果、免疫功能、抗病毒药物耐药情况。结果1073例HIV/AIDS患者中,抗病毒治疗后病毒完全抑制798例(74.37%),抗病毒治疗失败39例(3.63%)。免疫功能正常411例(38.30%)。CD4^(+)T淋巴细胞计数和病毒载量存在负相关关系(r_(s)=-0.166,P<0.001)。39例抗病毒治疗失败患者中,耐药发生率为20.51%(8/39),对核苷酸类反转录酶抑制剂(NRTIs)和非核苷类反转录酶抑制剂(NNRTIs)的耐药发生率分别为15.38%(6/39)、17.95%(7/39),对NRTIs和NNRTIs的多重耐药发生率为12.82%(5/39)。结论福州市HIV/AIDS患者抗病毒治疗效果良好,耐药发生率总体较低。Objective To discuss the effect of antiretroviral therapy(ART)and drug resistance for 1073 AIDS/HIV patients in Fuzhou city,so as to provide reference for further improvement of AIDS antiretroviral therapy.Methods A retrospective survey was conducted to collect the data of 1073 HIV/AIDS patients who received antiviral treatment in Fuzhou city from January 2019 to December 2020.The CD4^(+)T lymphocyte count,viral load and drug resistance of the patients after antiviral treatment were evaluated,and the antiviral treatment effect,immune function and drug resistance were evaluated.Results Among the 1073 cases,complete viral suppression was achieved in 798 patients(74.37%)through antiviral treatment.Treatment failure was observed in 39 cases(3.63%).A total of 411 patients(38.30%)exhibited normal immune function.The CD4^(+)T lymphocyte count and viral load exhibit a negative correlation(r_(s)=-0.166,P<0.001).Among 39 patients who failed antiviral treatment,the incidence of drug resistance was 20.51%(8/39).The incidence of resistance to nucleotide reverse transcriptase inhibitors(NRTIs)and non nucleoside reverse transcriptase inhibitors(NNRTIs)was 15.38%(6/39)and 17.95%(7/39),respectively.The incidence of multidrug resistance to NRTIs and NNRTIs was 12.82%(5/39).Conclusion The antiretroviral therapy in Fuzhou city has shown good efficacy,with an overall low occurrence rate of drug resistance.

关 键 词：抗病毒治疗 病毒载量 CD4^(+)T淋巴细胞 耐药 

分 类 号：R512.91[医药卫生—内科学] R978.7[医药卫生—临床医学]