海勤人员高尿酸血症和痛风的发生情况及影响因素分析  

Analysis of incidence and influencing factors of hyperuricemia and gout in naval officers and sailors

作　　者：魏金凤 刘武岩 姜梅 刘继良 刘畅 王卫红 刘丹颖 陈松楠 孙建新 李净 Wei Jinfeng;Liu Wuyan;Jiang Mei;Liu Jiliang;Liu Chang;Wang Weihong;Liu Danying;Chen Songnan;Sun Jianxin;Li Jing(Beidaihe Rehabilitation and Recuperation Center of PLA,Qinhuangdao 066100,China)

机构地区：[1]联勤保障部队北戴河康复疗养中心,秦皇岛066100

出　　处：《中华航海医学与高气压医学杂志》2024年第1期59-62,共4页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的探讨海勤人员高尿酸血症(HUA)和痛风的发生情况及其影响因素。方法收集2017年1月至2022年12月入住联勤保障部队北戴河康复疗养中心康复疗养的海勤人员1462例,经临床确诊HUA患者321例,包括无症状HUA患者279例为HUA组,痛风42例为痛风组,其余血尿酸(SUA)正常的1141例为正常组。依据年龄分为≤30岁、31~40岁和>40岁3个年龄段,比较其HUA和痛风的发生情况。统计3组人群年龄、SUA、体重指数(BMI)、腰臀比(WHR)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、尿素氮(BUN)、血肌酐(SCr)、收缩压(SBP)、舒张压(DBP)等数据,并分析HUA海勤人员SUA水平与上述临床指标的相关性。结果31~40岁、>40岁年龄段海勤人员HUA和痛风发生率均明显高于≤30岁(P<0.01)。HUA组和痛风组患者年龄、SUA、BMI、WHR、BUN、SCr、TG、TC、LDL、SBP、DBP较正常组明显增高,HDL-C明显降低;痛风组患者年龄、SUA、TG、LDL-C、DBP较HUA组明显增高(P<0.05或P<0.01)。HUA海勤人员SUA水平与年龄、BMI、WHR、SCr、TG、TC、LDL-C和DBP呈正相关(P<0.05或P<0.01)。结论海勤人员特定的环境因素易导致HUA、痛风的发生,HUA海勤人员SUA水平与年龄、BMI、WHR、SCr、TG、TC、LDL-C和DBP等临床指标密切相关。Objective To study the incidence and influencing factors of hyperuricemia(HUA)and gout in naval officers and sailors.Methods A total of 1665 naval officers and sailors admitted to Beidaihe Rehabilitation and Recuperation Center of PLA from January 2017 to December 2022 were selected.Among them,321 were diagnosed as HUA;279 asymptomatic HUA patients were assigned into HUA group and 42 HUA patients with gout were assigned into gout group,and the remaining 1141 patients with normal serum uric acid(SUA)were assigned into control group.The incidences of HUA and gout were compared in three age groups:≤30 years old,31 to 40 years old,and>40 years old.The data of age,SUA,body mass index(BMI),waist-hip ratio(WHR),triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,blood urea nitrogen(BUN),serum creatinine(SCr),systolic blood pressure(SBP),and diastolic blood pressure(DBP)of the three groups were recorded,and the correlation between SUA level of naval officers and sailors with hyperuricemia and the above-mentioned clinical indicators was analyzed.Results The incidences of HUA and gout in the naval officers and sailors aged from 31 to 40 years old and over 40 years old were all significantly higher than those under 30 years old(P<0.01).Compared with the control group,age,SUA,BMI,WHR,BUN,SCr,TG,TC,LDL,SBP,and DBP in the HUA group and the gout group were all increased significantly,while HDL-C was decreased significantly;compared with the HUA group,age,SUA,TG,LDL-C,and DBP in the gout group were increased significantly(P<0.05 or P<0.01).The level of SUA in the naval officers and sailors with HUA was positively correlated with age,BMI,WHR,Scr,TG,TC,LDL-C,and DBP(P<0.05 or P<0.01).Conclusion Among naval officers and sailors,hyperuricemia and gout are easily caused by specific environmental factors,and their serum uric acid levels are closely related to the clinical indicators such as age,BMI,WHR,SCr,TG,TC,LDL-C,and DBP.

关 键 词：高尿酸血症 海勤人员 痛风 血尿酸 

分 类 号：R835.2[医药卫生—航空、航天与航海医学]