内窥环境下多光谱血氧饱和度检测  

Multi-Spectral Blood Oxygen Saturation Detection in Endoscopic Environment

作　　者：章昶威 邹鸿博 齐伟明 朱文武 王立强 袁波[1] Zhang Changwei;Zou Hongbo;Qi Weiming;Zhu Wenwu;Wang Liqiang;Yuan Bo(College of Optical Science and Engineering,Zhejiang University,Hangzhou 310027,Zhejiang,China;Zhejiang Center for Medical Device Evaluation,Hangzhou 310009,Zhejiang,China;Research Center for Humanoid Sensing,Zhejiang Lab,Hangzhou 311100,Zhejiang,China)

机构地区：[1]浙江大学光电信息科学与工程学院,浙江杭州310027 [2]浙江省医疗器械审评中心,浙江杭州310009 [3]之江实验室类人感知研究中心,浙江杭州311100

出　　处：《光学学报》2024年第2期246-253,共8页Acta Optica Sinica

基　　金：国家重点研发计划(2021YFC2400103);之江实验室科研项目(2019MC0AD02,2022MG0AL01)。

摘　　要：采用蒙特卡罗模拟技术对血管组织在可见光波段的多光谱成像进行建模仿真,通过分析不同血氧饱和度下血液后向散射功率的绝对值、相对值、绝对差值和对比度,并考虑可能的干扰因素,优选出适合内窥环境下使用的450 nm、525 nm、630 nm和660 nm 4个成像波段。基于4个优选的成像波段展开了血氧饱和度检测的实验验证。在血管仿体组织上的实验结果表明,在95%的置信水平下,血氧饱和度的检测偏差为1.24%。研究结果验证了利用四波段进行内窥组织血氧饱和度检测的可行性。Objective Hypoxemia is a common clinical phenomenon that is closely associated with various pathological changes caused by a decrease in oxygen saturation to different degrees.We aim to develop a low-cost blood oxygen saturation detection technology that can be adapted to a wider range of endoscopes for clinical practice and patient diagnosis and treatment.By expanding the application scenarios of endoscopic blood oxygen detection and enriching its practical application value,we hope to help popularize the application of endoscopic technology in remote and resource-scarce areas and improve the coverage and quality of medical services.Methods We initially employ the Monte Carlo simulation technique to model and simulate multi-spectral imaging of blood vessel tissue in the visible light range.The absolute value,relative value,absolute difference,and contrast of the backscattering power of blood at different levels of oxygen saturation are analyzed.In response to the complexity of multispectral blood oxygen saturation detection in an endoscopic environment,the analytic hierarchy process(AHP)is used to comprehensively analyze various factors that could potentially interfere with the results.By adopting a hierarchical analysis approach,the factors that could potentially interfere with blood oxygen detection are categorized into four major groups:controllable conditions before the experiment,controllable conditions during the experiment,errors before the experiment,and errors during the experiment.After assigning importance ratings to these factors,questionnaires are distributed to laboratory researchers,physicians,and other professionals,so as to gather their opinions on the various sub-categories within each major group.By combining the opinions obtained through the questionnaire with AHP,we derive the importance weightings of the top 16 factors that could potentially interfere with the experimental results,and all weightings are below 0.06.Based on this analysis,four imaging bands suitable for endoscopic environment

关 键 词：医用光学 多光谱成像 内窥镜 血氧饱和度 蒙特卡罗仿真 

分 类 号：O433.1[机械工程—光学工程] TH776[理学—光学] R446.11[理学—物理]