Light-responsive Self-Immolative L-glutamic Acid-based Polyester Nanoparticles for Controlled Drug Release via Passerini Three-Component Polymerization  

作　　者：Xiao-Fei Sun Xu Zhang Shu-Ping Song Ya-Qun Yao Yan Zhang Cheng-Liang Wang Jing-Jiang Sun Qing-Fu Wang 

机构地区：[1]Key Laboratory of Rubber-plastics,Ministry of Education,School of Polymer Science and Engineering,Qingdao University of Science and Technology,Qingdao,266042,China [2]Qingdao Research Academy of Environmental Science,Qingdao,266012,China

出　　处：《Chinese Journal of Polymer Science》2024年第5期570-578,I0005,共10页高分子科学（英文版）

基　　金：This work was financially supported by the International Science and Technology Assistance Program of the Ministry of Science and Technology(No.KY202001016);Shandong Provincial Natural Science Foundation Magnitude Fundamental Research,China(No.ZR2022ZD11);Qingdao New Energy Shandong Laboratory Open Project(No.QNESL OP202312).

摘　　要：L-glutamic acid(LA)is a bio-based,non-toxic,environmentally friendly material derived from biomass.The present study reports the application of Passerini three-component polymerization(P-3CP)for the straightforward preparation of LA-based light-responsive polyesters(PLTDs)under mild conditions.PLTDs with molar masses up to 8500 g/mol and high yields exceeding 90%are obtained.The chemical structures and light-responsive self-immolative behavior of PLTDs are comprehensively characterized by employing ultraviolet-visible(UV-Vis)spectroscopy,size exclusion chromatography(SEC),nuclear magnetic resonance(NMR)spectroscopy,and liquid chromatography mass spectrometry(LC-MS).Meanwhile,monodisperse PLTD-based doxorubicin-loaded nanoparticles(PLTD-DOX-NP)(size=193 nm,PDI=0.018)are formulated by nanoprecipitation method.Upon light-induced depolymerization,the PLTD-DOX-NP undergoes rapid decomposition,resulting in a burst release of 80%cargo within 13 s.Furthermore,according to biological toxicity tests,the PLTD-NP possesses adequate biosafety,both before and after irradiation.Overall,the incorporation of P-3CP with biorenewable LA-based monomer adheres to the principles of green chemistry,significantly simplifying the synthetic pathway of light-responsive polymers.

关 键 词：L-glutamic acid Passerini three-component polymerization Light-responsive POLYESTER NANOPARTICLES 

分 类 号：TQ460.1[化学工程—制药化工] TQ317[一般工业技术—材料科学与工程] TB383.1