Phytoconstituents Profiling of Indigenous Herbal Drugs and Its in vitro Microbial,in Silico Biological Examination against Severe Acute Respiratory Syndrome Coronavirus 2  

作　　者：T.H.Mohamed Ahadu Shareef MMohamed Divan Masood Irfan Navabshan MSaiyad Musthafa 

机构地区：[1]Department of Chemistry,The New College(Autonomous),Affiliated to the University of Madras,Chennai,Tamil Nadu,India [2]School of Computer Applications,B.S.Abdur Rahman Crescent Institute of Science and Technology,Chennai,Tamil Nadu,India [3]Crescent School of Pharmacy,B.S.Abdur Rahman Crescent Institute of Science and Technology,Chennai,Tamil Nadu,India [4]Department of Zoology,The New College(Autonomous),Affiliated to the University of Madras,Chennai,Tamil Nadu,India

出　　处：《World Journal of Traditional Chinese Medicine》2024年第1期121-136,共16页世界中医药杂志（英文）

摘　　要：Background:Habb-E-Shifa,Hamdard Sualin,and Hamdard Joshanda traditional herbal medicines may promote host resistance against infection by bacteria,viruses,and fungi which are easily accessible at inexpensive with no complexity.These herbal medicines are used to cure sore throat,cough,fever,lung cancer,and asthma patients in developing South Asian countries.These traditional herbal medicines acted a crucial role in the prevention and control of coronavirus disease 2019(COVID-19).Aims and Objectives:This research article aimed at conducting phytochemistry,antimicrobial activity,COVID-19 docking and some spectroscopic(Infrared,Ultraviolet,13C-Nuclear Magnetic Resonance(13C-NMR),1H-NMR,and Mass Spectra)characterizations of the polyherbal drugs were carried out.Additionally,In-vitro and In-silico analyses were performed to measure activity against COVID-19.High Performance-Liquid Chromatography(HPLC),Gas Chromatography-Mass Spectrometry(GC-MS),antimicrobial,and docking studies were carried out.The preliminary phytochemical assay and bioactive compounds were screened using HPLC and GC-MS.The study is an attempt to assess the promising effects of selected polyherbal indigenous drugs such as Habb-E-Shifa,Hamdard Sualin,and Hamdard Joshanda phytoconstituents against the severe acute respiratory syndrome coronavirus-2(SARS-Co V-2).Materials and Methods:The extract of the selected polyherbal formulations showed high-to-moderate preventive effects on the growth inhibition in the pathogenic bacterium,namely Streptococcus oralis,Staphylococcus aureus,Propionibacterium acnes,Pseudomonas aeruginosa,Escherichia coli,and Proteus vulgaris,and three fungal Candida albicans,Aspergillus fumigatus,and Aspergillus niger.Further docking study evaluates the pharmacological activity of bioactive chemical compounds with SARS-Co V-2 NSP5(PDB ID:7nxh)and SARS-Co V-2 Omicron spike protein with human angiotensin-converting enzyme 2(ACE-2)(PDB ID:7wk6).Results:In this study,for the first time,we attempted to examine some spectroscopic characteri

关 键 词：ANTIMICROBIAL herbal drug Omicron and coronavirus disease 2019 PHYTOCHEMICALS SPECTROSCOPIC 

分 类 号：R284.1[医药卫生—中药学]