FGFs与糖尿病肾病、慢性肾病相关性研究进展  

Research progress on relationship between FGFs and diabetic nephropathy,chronic kidney disease

作　　者：杨羽甜 薄双玲[1] 赵慧 郭晨浩 张琪 胡晋丹 YANG Yutian;BO Shuangling;ZHAO Hui;GUO Chenhao;ZHANG Qi;HU Jindan(Department of Histology and Embryology,Fenyang College of Shanxi Medical University,Fenyang 032200,China)

机构地区：[1]山西医科大学汾阳学院组织胚胎学教研室,山西汾阳032200

出　　处：《生物技术》2024年第1期108-113,共6页Biotechnology

基　　金：吕梁市重点研发计划项目(2020SHFZ43);山西医科大学汾阳学院大学生创新创业训练项目(FDC202112)。

摘　　要：糖尿病肾病(DKD)和慢性肾脏病(CKD)是导致终末期肾病的重要病因,已成为全球性的公共健康问题,但其发病机制目前仍不明确,尚无有效的临床治疗手段。成纤维细胞生长因子(FGF)是一种信号调节蛋白,近年研究发现其家族成员,特别是FGF1、FGF21、FGF23与糖尿病肾病及慢性肾脏病的发生发展息息相关。该文总结了近年来FGFs与DKD、CKD相关性的临床及实验研究进展,以期为DKD、CKD的早发现、早干预及改善患者预后提供新思路。Diabetic nephropathy(DKD)and chronic kidney disease(CKD)are important causes of end-stage renal disease and have become a global public health problem,but their pathogenesis is still unclear and there is no effective clinical treatment.Fibroblast growth factor(FGF)is a signal regulatory protein,and recent studies have found that its family members,especially FGF1,FGF21,FGF23,are closely related to the occurrence and development of diabetic nephropathy and chronic kidney disease.This paper summarizes the clinical and experimental progress of the correlation between FGFs and DKD and CKD in order to early detection of DKD and CKD,Early intervention and improve patient prognosis to provide new ideas.

关 键 词：成纤维细胞生长因子 信号通路 糖尿病肾病 慢性肾脏病 临床应用 

分 类 号：R692[医药卫生—泌尿科学]