磁性金属-有机框架复合材料作为抗癌药物载体的研究进展  

Research Progress of Magnetic Metal-Organic Framework Composites as Anti-Cancer Drug Carriers

作　　者：付巧芳 吴瑛[1,3] FU Qiaofang;WU Ying(Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin,Xinjiang Production and Construction Corps,Alar 843300,China;School of Life Science and Technology,Tarim University,Alar 843300,China;College of Chemistry and Chemical Engineering,Tarim University,Alar 843300,China)

机构地区：[1]新疆生产建设兵团塔里木盆地生物资源保护与利用重点实验室,新疆阿拉尔843300 [2]塔里木大学生命科学与技术学院,新疆阿拉尔843300 [3]塔里木大学化学化工学院,新疆阿拉尔843300

出　　处：《中国兽医杂志》2024年第4期104-110,共7页Chinese Journal of Veterinary Medicine

基　　金：有机无机复合材料国家重点实验室开放课题(201501008)。

摘　　要：金属-有机框架(MOFs)凭借其高孔隙率和大比表面积所带来的载药空间,成为药物递送领域研究的热点。近年来,兴起了一种新型磁性框架复合材料(MFCs),MFCs保留了MOFs的载药率和生物安全性较高的性能,同时增加了磁靶向和磁热疗性能。本文对MFCs的制备方法、种类、作为抗癌药物载体的特点以及药物递送时的作用方式进行综述,并对MFCs在实际应用中面临的挑战进行总结,以期为未来的研究工作提供参考依据。Metal-organic frameworks(MOFs),with their high porosity and large specific surface area,have become a hot research topic in the field of drug delivery.In recent years,a new type of magnetic framework composites(MFCs)has emerged.MFCs retain the drug loading capacity of MOFs and their relatively high biocompatibility,while also enhancing magnetic targeting and magnetic hyperthermia performance.Therefore,this article reviews the synthesis methods,types,characteristics as drug carriers for anti-cancer drugs,and the mode of action during drug delivery of MFCs.Finally,it summarizes the challenges faced by MFCs in practical applications and prospect future research directions.

关 键 词：磁性-金属有机框架 癌症 磁性粒子 靶向 磁热疗 

分 类 号：S854.5[农业科学—临床兽医学]