马红球菌病的初步诊断和治疗  

Preliminary Diagnosis and Treatment of Rhodococcus equi Disease

作　　者：余万里 马玉辉 王彦峰 马思远 刘璐[1] 刘来珍 蔡涛[4] 赵红琼[1] YU Wanli;MA Yuhui;WANG Yanfeng;MA Siyuan;LIU Lu;LIU Laizhen;CAI Tao;ZHAO Hongqiong(College of Veterinary Medicine,Xinjiang Agricultural University,Urumqi 830052,China;Xinjiang Bazhou Animal Disease Control and Diagnosis Center,Bazhou 841000,China;Animal Husbandry and Veterinary Bureau of Zhaosu County,Yili 835600,China;Xinjiang Agricultural Vocational Technical College,Changji 831100,China)

机构地区：[1]新疆农业大学动物医学学院,新疆乌鲁木齐830052 [2]新疆巴州动物疾病控制与诊断中心,新疆巴州841000 [3]新疆昭苏县畜牧兽医发展中心,新疆伊犁835600 [4]新疆农业职业技术学院,新疆昌吉831100

出　　处：《中国兽医杂志》2024年第4期146-151,共6页Chinese Journal of Veterinary Medicine

基　　金：新疆上海合作组织科技伙伴计划及国际科技合作计划项目(2022E01027);新疆维吾尔自治区区域协同创新专项(科技援疆计划)项目(2020E0236)。

摘　　要：为探究马红球菌的致病性和治疗方案。本试验对4匹疑似感染马红球菌的患驹进行临床检查并采集肛拭子样品进行实验室检测。结果显示,4匹患驹均出现体温升高、呼吸困难和脓性鼻液等马红球菌病典型临床症状;对采集的样品进行分离培养,经PCR鉴定该菌株为致病性马红球菌,使用利福平和大环内酯类抗生素联合用药对感染患驹进行治疗后,其中3匹患驹治愈,1匹患驹因发病初期病情较严重,治疗无效死亡,对其进行剖检,肺部出现典型病变。本试验表明,马红球菌具有较强的致病性,严重时可导致马匹死亡,使用利福平和大环内酯类抗生素联合用药对马红球菌病能够起到较好的治疗效果。To investigate the pathogenicity and therapeutic schedule for Rhodococcus equi.Clinical examinations were conducted on four suspected cases of Rhodococcus equi infection in foals,and rectal swab samples were collected for laboratory testing.The results showed that all four affected foals exhibited typical clinical symptoms of rhodococcal disease,including fever,respiratory distress,and purulent nasal discharge.Isolation and culture of the collected samples identified the pathogenic strain as Rhodococcus equi via PCR.Treatment with a combination of rifampicin and macrolide antibiotics resulted in the recovery of three affected foals,while one foal with severe initial symptoms did not respond to treatment and died.Post-mortem examination revealed typical lesions in the lungs.This study demonstrates that Rhodococcus equi has strong pathogenicity and can lead to fatalities in horses.Treatment with rifampicin and macrolide antibiotics can effectively treat rhodococcal disease.

关 键 词：马 马红球菌 诊断 治疗 

分 类 号：S821.7[农业科学—畜牧学]