血清生长激素释放肽及葡萄糖转运蛋白-1 mRNA对重度子痫前期的预测价值  

Predictive value of serum growth hormone releasing peptide and glucose transporter-1 mRNA for severe preeclampsia

作　　者：高华 孙凡 雷晓阁 韩程成 GAO Hua;SUN Fan;LEI Xiaoge;HAN Chengcheng(Department of Obstetrics,Northwest Women and Children′s Hospital,Xi′an,Shaanxi 710061,China)

机构地区：[1]西北妇女儿童医院产科,陕西西安710061

出　　处：《国际检验医学杂志》2024年第8期932-935,共4页International Journal of Laboratory Medicine

基　　金：中国疾病预防控制中心、妇幼保健中心2020年度母婴营养与健康研究项目(2020FYH018)。

摘　　要：目的 探讨孕产妇血清生长激素释放肽(Ghrelin)及葡萄糖转运蛋白-1(GTUT-1)mRNA对子痫前期(PE)的预测价值。方法 以2019年1月至2023年1月该院收治的267例经临床诊断为PE的孕产妇作为研究对象,根据病情严重程度将其分为轻度RE组(152例)和重度PE组(115例)。另选取同期在该院产检的94例健康孕产妇作为对照组。比较对照组、轻度PE组及重度PE组孕产妇血清Ghrelin及GTUT-1水平,采用多元Logistic回归分析PE病情严重程度的影响因素,受试者工作特征(ROC)曲线分析Ghrelin及GTUT-1对PE的预测价值。结果 对照组、轻度PE组及重度PE组血清Ghrelin及GTUT-1 mRNA依次升高,组间比较差异均有统计学意义(P<0.05);多元Logistic回归分析显示,UA、Ghrelin、GLUT-1 mRNA、CRP、IL-6为重度PE为重度PE的独立危险因素(P<0.05);ROC曲线分析显示,Ghrelin和GLUT-1 mRNA预测重度PE的cut-off值分别为19.56μg/L、1.11,对应曲线下面积(AUC)分别为为0.756、0.769。结论 孕产妇血清Ghrelin及GTUT-1 mRNA对重度PE有一定预测价值。Objective To investigate the predictive value of serum growth hormone releasing peptide(Ghrelin)and glucose transporter-1(GTUT-1)mRNA for severe preeclampsia(PE)in pregnant women.Methods A total of 267 pregnant women clinically diagnosed with PE admitted to the hospital from January 2019 to January 2023 were divided into mild RE group(152 cases)and severe PE group(115 cases)according to the severity of the disease.Another 94 healthy pregnant women were selected as the control group.Serum levels of Ghrelin and GTUT-1 in the control group,the mild PE group and the severe PE group were compared.Multiple Logistic regression was used to analyze the influencing factors of the severity of PE disease,and the predictive value of Ghrelin and GTUT-1 on PE was analyzed by receiver operating characteristic(ROC)curve.Results Serum Ghrelin and GTUT-1 mRNA levels in control group,mild PE group and severe PE group were increased successively,with statistical significance(P<0.05).Multiple Logistic regression analysis showed that UA,Ghrelin,GLUT-1 mRNA,CRP and IL-6 were independent risk factors for severe PE(P<0.05).ROC curve analysis showed that the cut-off value of Ghrelin and GLUT-1 mRNA to predict severe PE was 19.56μg/L and 1.11,respectively,and the corresponding area under the curve(AUC)was 0.756 and 0.769,respectively.Conclusion Serum Ghrelin and GTUT-1 mRNA have certain predictive value for pregnant women with severe PE.

关 键 词：子痫前期 生长激素释放肽 葡萄糖转运蛋白-1 危险因素 

分 类 号：R714.252[医药卫生—妇产科学]