妊娠早期血清铁蛋白、红细胞沉降率对复发性流产再次妊娠孕妇早产发生的预测价值  

Prognostic value of serum ferritin and erythrocyte sedimentation rate in early pregnancy for premature delivery in recurrent spontaneous abortion

作　　者：马元岚 张正勤 秦燕翔 MA Yuanlan;ZHANG Zhengqin;QIN Yanxiang(Department of Obstetrics and Gynecology,Lu′an Civily Hospital,Lu′an,Anhui 237008,China;Department of Clinical Laboratory,Lu′an Civily Hospital,Lu′an,Anhui 237008,China)

机构地区：[1]六安世立医院妇产科,安徽六安237008 [2]六安世立医院检验科,安徽六安237008

出　　处：《国际检验医学杂志》2024年第8期946-949,954,共5页International Journal of Laboratory Medicine

基　　金：安徽省卫生健康委科研项目(AHWJ2021b011)。

摘　　要：目的 探讨妊娠早期血清铁蛋白、红细胞沉降率对复发性流产(RSA)再次妊娠孕妇早产发生的预测价值。方法 选取2018年1月至2022年5月在该院进行产检的250例RSA再次妊娠孕妇作为研究对象,采集孕妇一般资料、孕12周时血清铁蛋白、外周血红细胞沉降率及其他实验室指标;所有孕妇均随访至分娩,根据早产发生情况分为早产组与足月分娩组,比较两组相关资料及实验室指标,并分析血清铁蛋白、外周血红细胞沉降率对RSA再次妊娠孕妇早产发生的预测价值。结果 250例孕妇中32例出现早产,占12.80%;早产组孕妇年龄大于足月分娩组,血清铁蛋白、外周血血红蛋白水平低于足月分娩组,外周血红细胞沉降率高于足月分娩组,差异均有统计学意义(P<0.05);点二列相关性分析显示,年龄、外周血红细胞沉降率与RSA再次妊娠孕妇早产发生呈正相关(P<0.05);血清铁蛋白、外周血血红蛋白水平与RSA再次妊娠孕妇早产发生呈负相关(P<0.05);Logistic回归分析发现,血清铁蛋白、外周血血红蛋白水平高是RSA再次妊娠孕妇早产发生的保护因素(OR=0.465、0.796,均P<0.05),外周血红细胞沉降率高是RSA再次妊娠孕妇早产发生的危险因素(OR=2.504,P<0.05);绘制受试者工作曲线(ROC)曲线发现,血清铁蛋白、外周血红细胞沉降率单一及联合预测RSA再次妊娠孕妇早产发生的曲线下面积(AUC)分别为0.723、0.883、0.906,单一指标检测均有一定预测价值,二者联合检测具有较高预测价值。结论 RSA再次妊娠孕妇妊娠早期血清铁蛋白、外周血红细胞沉降率与早产发生有关,二者可作为临床早期预测孕妇早产发生风险的辅助指标。Objective To investigate the predictive value of serum ferritin and erythrocyte sedimentation rate levels in early pregnancy for premature delivery in pregnant women with recurrent spontaneous abortion(RSA).Methods A total of 250 pregnant women with RSA repregnancy who underwent prenatal examination in the hospital from January 2018 to May 2022 were selected as the study objects.General data,serum ferritin at 12 weeks of pregnancy,peripheral blood erythrocyte sedimentation rate and other laboratory indicators were collected.All pregnant women were followed up until delivery,and were divided into premature delivery group and full-term delivery group according to the occurrence of premature delivery.The relevant data and laboratory indicators of the two groups were compared,and the predictive value of serum ferritin and peripheral blood erythrocyte sedimentation rate for the occurrence of premature delivery in pregnant women with RSA was analyzed.Results Premature birth occurred in 32 of 250 pregnant women,accounting for 12.80%.The pregnant women in the premature delivery group were older than those in the full-term delivery group,the levels of serum ferritin and peripheral blood hemoglobin were lower than those in the full-term delivery group,and the peripheral blood erythrocyte sedimentation rate was higher than that in the full-term delivery group,with statistical significance(P<0.05).The point two column correlation analysis showed that age,peripheral blood sedimentation rate level were positively correlated with the incidence of premature delivery in pregnant women with RSA(P<0.05).The levels of serum ferritin and peripheral blood hemoglobin were negatively correlated with the incidence of premature delivery in pregnant women with RSA(P<0.05).Logistic regression analysis showed that high levels of serum ferritin and peripheral blood hemoglobin were protective factors for premature delivery in pregnant women with RSA(OR=0.465,0.796,both P<0.05),and high levels of peripheral blood erythrocyte sedimentation rate

关 键 词：复发性流产 妊娠 铁蛋白 红细胞沉降率 早产 

分 类 号：R714.21[医药卫生—妇产科学]