过敏性鼻炎患儿血清HLA-G、Claudin-1水平变化及与病情严重程度的关系  

Changes of serum HLA-G and Claudin-1 levels in children with allergic rhinitis and their relationship with the severity of the disease

作　　者：李娟 胡广成 陈欢欢 王昕 董晓莎 曹焕珍[1] LI Juan;HU Guangcheng;CHEN Huanhuan;WANG Xin;DONG Xiaosha;CAO Huanzhen(Department of Pediatrics,Sanmenxia Hospital of Huanghe River,Sanmenxia,Henan 472000,China)

机构地区：[1]黄河三门峡医院儿科,河南三门峡472000

出　　处：《国际检验医学杂志》2024年第8期955-958,共4页International Journal of Laboratory Medicine

基　　金：中国水利水电第十一工程有限公司科技项目(2021-217)。

摘　　要：目的 探讨过敏性鼻炎患儿血清人类白细胞抗原G(HLA-G)、封闭蛋白1(Claudin-1)水平的变化及其与病情严重程度的关系。方法 选取该院2021年7月1日至2022年7月1日收治的86例过敏性鼻炎患儿作为观察组,同期在该院体检的34例健康儿童作为对照组。采用酶联免疫吸附试验检测两组血清HLA-G、Claudin-1水平并进行比较。比较治疗前及治疗过程中观察组患儿过敏性鼻炎症状量表(SFAR)和伴随症状的视觉模拟量表(VAS)评分,分析不同SFAR、VAS评分患儿血清HLA-G、Claudin-1水平。采用Spearman法分析血清HLA-G、Claudin-1水平与SFAR和VAS评分的相关性。结果 与对照组相比,观察组血清HLA-G水平较高,Claudin-1水平较低,差异均有统计学意义(P<0.05);观察组在治疗30周、1年后HLA-G水平明显降低,Claudin-1水平明显升高,差异均有统计学意义(P<0.05)。与治疗前比较,治疗30周、1年后观察组SFAR评分降低,VAS评分轻度/中重度比例减少,差异有统计学意义(P<0.05)。相关性分析结果显示,过敏性鼻炎患儿血清HLA-G水平与病情严重程度呈正相关(r_(SFAR)=0.433,P<0.05;r_(VAS)=0.442,P<0.05),Claudin-1水平与病情严重程度呈负相关(r_(SFAR)=-0.483,P<0.05;r_(VAS)=-0.468,P<0.05)。结论 过敏性鼻炎患儿血清HLA-G水平较高,Claudin-1水平较低,且与病情严重程度相关,二者具有作为诊断和评价疾病标志物的潜力。Objective To investigate the changes of serum human leukocyte antigen G(HLA-G)and Claudin-1 levels in children with allergic rhinitis and their relationship with the severity of the disease.Methods From July 1,2021 to July 1,2022,86 children with allergic rhinitis who were admitted to this hospital were collected as the observation group,and 34 healthy children who underwent physical examination in the hospital during the same period were selected as the control group.Serum HLA-G and Claudin-1 levels were detected by enzyme-linked immunosorbent assay and compared.The scores of allergic rhinitis scale(SFAR)and visual analogue scale(VAS)of accompanying symptoms were compared before and during treatment in the observation group,and serum HLA-G and Claudin-1 levels of children with different SFAR and VAS scores were analyzed.The correlation between serum HLA-G and Claudin-1 levels and SFAR and VAS scores was analyzed by Spearman method.Results Compared with the control group,the serum HLA-G level in the observation group was significantly higher and Claudin-1 level was significantly lower(P<0.05).At 30 weeks and 1 year after treatment,the HLA-G level in the observation group was significantly decreased and the Claudin-1 level was significantly increased(P<0.05).Compared with before treatment,the SFAR score of the observation group decreased at 30 weeks and 1 year after treatment,and the proportion of moderate and severe patients decreased,and the differences were statistically significant(P<0.05).Correlation analysis showed that serum HLA-G level was positively correlated with the severity of allergic rhinitis(r_(SFAR)=0.433,P<0.05;r_(VAS)=0.442,P<0.05),and Claudin-1 level was negatively correlated with the severity of the disease(r_(SFAR)=-0.483,P<0.05;r_(VAS)=-0.468,P<0.05).Conclusion Serum levels of HLA-G and Claudin-1 are higher in children with allergic rhinitis,and are correlated with the severity of the disease.Both of them may have potential as markers for diagnosis and evaluation of the disease.

关 键 词：过敏性鼻炎 人类白细胞抗原G 封闭蛋白1 疾病标志物 

分 类 号：R765.21[医药卫生—耳鼻咽喉科] R446.6[医药卫生—临床医学]