稀土上转换发光材料的设计及在光动力治疗中的应用研究进展  

Research Progress in the Design of Rare-earth Up-conversion LuminescentMaterials and Their Application in Photodynamic Therapy

作　　者：甘晓明 苏玉仙 应文伟 王建峰[2] 刘力[1] 周晓峰[2] 温世鹏[1] GAN Xiaoming;SU Yuxian;YING Wenwei;WANG Jianfeng;LIU Li;ZHOU Xiaofeng;WEN Shipeng(Beijing Engineering Research Center of Advanced Elastomers,Beijing University of Chemical Technology,Beijing 100029,China;Department of Urology,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]北京化工大学北京市先进弹性体工程技术研究中心,北京100029 [2]中日友好医院泌尿外科,北京100029

出　　处：《材料导报》2024年第8期95-106,共12页Materials Reports

摘　　要：作为一种新兴的无创治疗方法,光动力治疗在癌症治疗方面具有副作用小、累积毒性小、有效杀伤肿瘤以及精准的靶向治疗而不损伤邻近组织等优势,是理想的癌症治疗方法之一。本文首先简要概括了光动力治疗的机理、基本要素以及细胞作用机制,讨论了稀土上转化发光材料的设计特点以及光动力治疗对上转化发光材料的要求,进一步详述了上转换发光纳米材料、光敏剂以及靶向体的材料结合方式和应用效果,最后综述了光动力治疗和放疗、化疗及光热治疗相结合的协同治疗的进展。As an emerging non-invasive therapeutic approach, photodynamic therapy is an ideal cancer treatment method due to the low number of side effects, low cumulative toxicity, effective tumor destruction, and precise targeting without damaging adjacent tissues. In this review, we first briefly outline the mechanism, basic elements, and cellular reaction mechanisms of photodynamic therapy. After that, the design features of rare-earth up-conversion luminescent materials and the requirements of photodynamic therapy for up-conversion luminescent materials are discussed. In addition, the material combination methods of up-conversion luminescent nanomaterials, photosensitizers, and targeting substances, as well as the application effects, are summarized. Lastly, the progress of synergistic therapy combining photodynamic therapy with radiotherapy, che- motherapy , and photothermal therapy is reviewed.

关 键 词：光动力治疗 稀土上转换发光材料 光敏剂 癌症治疗 

分 类 号：TB33[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]