血清BMP及PPARγ水平与中轴型脊柱关节炎的骶髂关节脂肪化生的相关性研究  

Exploring the correlations of BMP and PPARγ with fat metaplasia associated in spondyloarthritis

作　　者：张宪萌 谭敏 李文花 张瑞 毛婧 沈海丽[2] Zhang Xianmeng;Tan Min;Li Wenhua;Zhang Rui;Mao Jing;Shen Haili(The Second Clinical Medical School,Lanzhou University,Lanzhou 730030,China;Department of Rheumatology and Immunology,The Second Hospital of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]兰州大学第二临床医学院,甘肃兰州730030 [2]兰州大学第二医院风湿免疫科,甘肃兰州730030

出　　处：《兰州大学学报（医学版）》2024年第2期48-54,共7页Journal of Lanzhou University（Medical Sciences）

基　　金：甘肃省科技计划基金资助项目(21JR7RA437)。

摘　　要：目的本研究旨在调查中轴型脊柱关节炎(axSpA)患者血清中骨形态发生蛋白(BMP)和过氧化物酶体增殖激活受体γ(PPARγ)的水平与脂肪化生的相关性,进而评估脂肪化生严重程度并预测早期结构进展。方法纳入30名axSpA病例和34名健康者作为对照组,采用Logistic回归分析同期临床、影像资料及血清学指标。结果病例组的血清BMP4,BMP9和PPARγ水平高于健康组,差异均具有统计学意义(均P<0.001)。axSpA患者的脂肪化生程度与血清BMP4(r=0.581,P<0.001)和PPARγ(r=0.507,P=0.004)均具呈正相关关系。重度脂肪化生组的血清BMP4(17.290±7.880 pg/mL)高于无、轻度脂肪化生组(9.131±4.087 pg/mL),差异具有统计学意义(P=0.002);PPARγ在重度脂肪化生组(104.561±49.764 pg/mL)亦高于无、轻度脂肪化生组(64.392±27.007 pg/mL),差异具有统计学意义(P=0.045)。BMP4水平的升高可能是axSpA患者重度脂肪化生的危险因素(OR=1.367,95%CI:[1.026,1.822],P=0.033)。结论血清BMP4和PPARγ水平有助于评估axSpA患者的脂肪化生程度。Objective To investigate the serum levels of bone morphogenetic proteins(BMPs)and peroxisome proliferator-activated receptor gamma(PPARγ)at various stages of fat metaplasia in axial spondyloarthritis(axSpA),aiming at assessing the severity of fat metaplasia and predict early structural progression in axSpA.Methods Thirty axSpA patients and 34 healthy controls were included.The serum levels of BMP2,BMP4,BMP9 and PPARγwere analyzed.The study employed the Logistic regression analysis for predictive value assessment.Results The serum levels of BMP4,BMP9,PPARγin the case group were significantly higher than those in the healthy group,with all differences being statistically significant(all P<0.001).The degree of fat metaplasia in patients with axSpA was positively correlated with serum BMP4(r=0.581,P<0.001)and PPARγ(r=0.507,P=0.004).The serum BMP4 levels in the severe fat metaplasia group(17.290±7.880 pg/mL)were significantly higher than those in the no or mild fat metaplasia group[(9.131±4.087)pg/mL],with a significant difference(P=0.002).Similarly,PPARγlevels in the severe fat metaplasia group[(104.561±49.764)pg/mL]were also significantly higher than those in the no or mild fat metaplasia group[(64.392±27.007)pg/mL],with a significant difference(P=0.045).Elevated levels of BMP4 might be a risk factor for severe fat metaplasia in axSpA(OR=1.367,95%CI:[1.026,1.822],P=0.033).Conclusion Serum BMP4 and PPARγlevels are crucial for assessing fat metaplasia in axSpA patients.

关 键 词：中轴型脊柱关节炎 脂肪化生 骶髂关节 骨形态发生蛋白 过氧化物酶体增殖激活受体 

分 类 号：R593.23[医药卫生—内科学]