马钱子碱抗肿瘤作用的研究进展  

Research progress on antticancer effects of brucine

作　　者：余源 黄媚娟[1] YU Yuan;HUANG Meijuan(West China Hospital,Sichuan University,Chengdu,Sichuan,610041 R.P.China)

机构地区：[1]四川大学华西医院,四川成都610041

出　　处：《华西药学杂志》2024年第2期231-234,共4页West China Journal of Pharmaceutical Sciences

基　　金：四川大学华西医院临床研究孵化项目重点项目(2021HXFH055)。

摘　　要：马钱子碱具有抗炎镇痛、调节神经系统、抗心律失常、抗血栓、促进成骨等作用。将马钱子碱用于治疗乳腺癌、肝癌、结直肠癌等疾病的研究日益增多。现综述近年来有关马钱子碱抗肿瘤作用的研究进展。Brucine is one of the main components derived from the dried mature seeds of Strychnos nux-vomica L.and S.Prerriana A.W.Hill.Brucine has been proved possessing many effects,such as anti-inflammatory and analgesic,regulating the nervous system,anti-arrhythmia,antithrombotic,promoting osteogenesis.It has been used in the treatment of diseases including osteoarthritis,paralysis,scabies and so on.The anti-tumor effect of brucine in diseases such as breast cancer,liver cancer,colorectal cancer and other diseases has become increasingly active.The recent research progress on the antitumor effect of brucineis reviewed.

关 键 词：马钱子碱 马钱 云南马钱 抗肿瘤 肝癌 三阴性乳腺癌 肺癌 结肠癌 多发性骨髓瘤 研究进展 

分 类 号：R96[医药卫生—药理学]