PET双显像剂分离方法研究进展  

Research progress on PET dual-tracer separation methods

作　　者：龚坦 尚斐[1] 刘帅[1] 霍力 Gong Tan;Shang Fei;Liu Shuai;Huo Li(School of Medical Technology,Beijing Institution of Technology,Beijing 100081,China;Department of Nuclear Medicine,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine,Beijing 100730,China)

机构地区：[1]北京理工大学医学技术学院,北京100081 [2]中国医学科学院、北京协和医学院北京协和医院核医学科、核医学分子靶向诊疗北京市重点实验室,北京100730

出　　处：《中华核医学与分子影像杂志》2024年第4期248-252,共5页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：国家自然科学基金(82102136)。

摘　　要：双显像剂PET显像能够为疾病诊断提供更为全面的临床信息。如何通过单次显像实现双显像剂显像是当前核医学领域研究热点,其核心技术问题是在混合显像剂信号中准确分离出单一显像剂信息。近20年来,不同显像剂的分离方法不断被提出,2种显像剂之间的注射间隔也在不断缩短。该文对近年来提出的双显像剂分离技术进行汇总,介绍了代表性技术的实现手段,总结了各种方法的优势,并展望其发展方向。Dual-tracer PET imaging can provide more comprehensive clinical information for disease diagnosis.How to achieve dual-tracer imaging through single imaging session is one of the hot topics in the field of nuclear medicine.The key issues in achieving dual-tracer imaging with a single scan is the accurate separation of single-tracer information from the mixed tracer signal.In the last two decades,separation methods for different tracers have been proposed,and the injection interval between two tracers was reduced.This paper summarizes recent dual-tracer separation methods.The basic principles,features and advantages of separation methods are analyzed.Besides,the outlook on the future development of dual-tracer separation is also discussed in the present review.

关 键 词：正电子发射断层显像术 图像处理 计算机辅助 发展趋势 

分 类 号：R817.4[医药卫生—影像医学与核医学]