对羟苯基丙酮酸双加氧酶的研究进展  

Review of 4-hydroxyphenylpyruvate dioxygenase

作　　者：林若煊 邹用科 柳国蓉 董进 于欣禾 林红艳 杨光富[1] LIN Ruoxuan;ZOU Yongke;LIU Guorong;DONG Jin;YU Xinhe;LIN Hongyan;YANG Guangfu(Central China Normal University,National Key Laboratory of Green Pesticide,Wuhan 430079,China)

机构地区：[1]华中师范大学绿色农药全国重点实验室,武汉430079

出　　处：《农药学学报》2024年第2期266-277,共12页Chinese Journal of Pesticide Science

基　　金：国家自然科学基金项目(22377031);武汉市知识创新专项(2022013301015174);湖北省重点研发计划(022BBA001).

摘　　要：农药作用靶标或作用机制的创新是农药科学研究需要解决的关键科学问题之一。对羟苯基丙酮酸双加氧酶(4-hydroxyphenylpyruvate dioxygenase,HPPD)是生物体酪氨酸代谢途径中的关键酶,在不同的生物体内参与的代谢路径不同。前期的研究表明,HPPD抑制剂在医药和除草方面发挥了较大的作用,而近期的研究发现其在抑菌和杀蚊等方面也表现出了潜在的应用价值。本文概述了HPPD在不同生物体中的生理功能,介绍了HPPD在人、植物、吸血节肢动物、真菌体内参与的代谢过程,总结了不同种属来源HPPD的三维结构,概述了HPPD作为靶标在医药以及农药(除草、杀虫、杀菌等)方面的研究现状并进行了展望。Innovating the action targets and mechanism of pesticides represents one of the critical scientific challenges necessitating resolution within the realm of pesticide science research.4-Hydroxyphenylpyruvate dioxygenase(HPPD)is an essential enzyme in the tyrosine metabolism pathway,with varying metabolic roles across different organisms.Exploratory research indicates that HPPD plays a substantial role in pharmaceuticals and herbicide applications.Recent studies unveiled the potential HPPD inhibitors in antifungal agents and mosquito repellents,emphasizing its versatile and promising applications.Consequently,this review summarizes HPPD's physiological roles in diverse organisms,detailing its metabolic functions in humans,blood-feeding arthropods,plants,and fungi.It provides a comparative analysis of HPPD crystal structures from different species and discusses its applications in medicine and pesticides(herbicides,insecticides,and fungicides)along with future research perspective.

关 键 词：对羟苯基丙酮酸双加氧酶(HPPD) 农药靶标 绿色农药 研究进展 

分 类 号：TQ450.1[化学工程—农药化工]