NH_(2)-ZIF-7 MOFs负载羧基化苯并异噻唑啉酮防污剂的制备和抗菌防污性能研究  

Preparation and Antibacterial and Antifouling Properties of Carboxylated Benzisothiazolinone Biocide Loaded NH_(2)-ZIF-7 MOFs

作　　者：张馨 郝晓娴 刘文静 赵海超 郑文茹 蓝席建 ZHANG Xin;HAO Xiaoxian;LIU Wenjing;ZHAO Haichao;ZHENG Wenru;LAN Xijian(Key Laboratory of Marine Materials and Related Technologies,Ningbo Institute of Materials Technology andEngineering,Chinese Academy of Sciences,Zhejiang Ningbo 315201,China;College of Materials Science andEngineering,Shenyang University of Chemical Technology,Shenyang 110142,China)

机构地区：[1]中国科学院宁波材料技术与工程研究所中国科学院海洋新材料与应用技术重点实验室,浙江宁波315201 [2]沈阳化工大学材料科学与工程学院,沈阳110142

出　　处：《表面技术》2024年第8期107-118,共12页Surface Technology

基　　金：宁波市科技创新2025重大专项(2020Z053);浙江省重点研发项目(2022C01213)。

摘　　要：目的开发长效缓释且具有生物相容的绿色环保防污剂,消除防污剂在涂层中初期“爆释”、后期无法释放的弊端,实现新型缓释剂长效防污的功效。方法通过简单的浸渍法负载防污剂分子,实现有效且缓慢释放;通过SEM、TEM观察负载前后纳米粒子的形貌;通过FT-IR、XRD、TGA、XPS、BET探究客体分子与纳米容器间的耦合作用,利用UV-Vis测试其释放性能;通过抑菌圈、平板菌落计数法、浊度法测试其抑菌性能;通过激光共聚焦观察涂层表面防细菌/藻类贴附性能。结果氨基ZIF-7(NH_(2)-ZIF-7)成功负载羧基化1,2-苯并异噻唑啉-3-酮(BIT-COOH),实现了有效封装和稳定释放,并且金属有机框架材料负载后(NH_(2)-ZIF-7@BIT-COOH),革兰氏阴性菌(E.coli)和革兰氏阳性菌(S.aureus)的抑菌圈直径分别提高至(21.7±0.2)和(21.7±0.3)mm。进一步利用激光共聚焦观察涂层表面的细菌/藻类贴附情况,表明添加质量分数4%NH_(2)-ZIF-7@BIT-COOH的混合树脂涂层具有优异的防细菌/藻类贴附性能。结论利用NH_(2)-ZIF-7封装BIT-COOH防污剂,可有效捕获、稳定释放并具有优异的抗菌性能,另外在丙烯酸树脂涂层中加入NH_(2)-ZIF-7@BIT-COOH新型缓释防污剂能够有效抑制细菌/海藻的贴附,为新型缓释长效广谱低毒的防污剂开发提供了新的思路。Marine biofouling,caused by attachment of organism to solid surface,is a worldwide issue that affects the exploitation of marine resources.The use of organic coatings containing various antifoulants is currently the most economical,convenient and effective strategy to solve this problem.In view of the current antifouling agents,the overuse of antifouling agents in the coating at the early stage leads to explosive release,while the release rate stabilizes in the middle and late stages,so its concentration is not sufficient to inhibit the growth of fouling substances.Therefore,how to reduce the amount of antifouling agent used and effectively control the release rate of antifouling agents while ensuring antifouling efficiency is the main research direction in the field of antifouling coatings.In this study,an amine functionalized ZIF-7(NH_(2)-ZIF-7)metal-organic framework nanocontainers with mesoporous structure were successfully prepared,and a liquid-phase diffusion method was used to effectively capture carboxylated 1,2-Benzoisothiazolin-3-one(BIT-COOH).The morphology of nanoparticles before and after encapsulation of antifouling agent was characterized by SEM and TEM.The successful loading guest molecules in nanocontainers were investigated by FT-IR,XRD,TGA,XPS and their nitrogen adsorption-desorption curve,and the release performance was tested by UV-Vis.The bacteriostatic activity was tested by zone of inhibition method,plate colony counting method and turbidity method.The anti-bacterial/algae adhesion performance of the coating surface was observed by the bio-laser confocal microscope.The results showed that the NH_(2)-ZIF-7 successfully wrapped the BIT-COOH,achieving effective capture and stable release.The inhibition performance against Gram-negative bacteria(E.coli)and Gram-positive bacteria(S.aureus)was significantly higher than that of NH_(2)-ZIF-7 carriers,and the diameter of inhibition zone increased to(21.7±0.2)and(21.7±0.3)mm,respectively.Further,the antibacterial performance of the acrylic hybrid

关 键 词：金属有机框架材料 1 2-苯并异噻唑啉-3-酮 缓释 抗菌 防污 涂层 

分 类 号：TG172[金属学及工艺—金属表面处理]