艾司氯胺酮在临床麻醉中的应用研究进展  

Research progress on the application of esketamine in clinical anesthesia

作　　者：肖玉 刘昕哲 高金霞[1] XIAO Yu;LIU Xinzhe;GAO Jinxia(Department of Anesthesiology,the Second Hospital of Dalian Medical University,Dalian 116023,China)

机构地区：[1]大连医科大学附属第二医院麻醉科,辽宁大连116023

出　　处：《大连医科大学学报》2024年第1期80-86,共7页Journal of Dalian Medical University

摘　　要：氯胺酮曾经作为唯一具有镇痛效果的麻醉药在临床上被广泛使用,但由于明显的拟精神病性不良反应,现其应用已大大减少。艾司氯胺酮是氯胺酮的右旋体,对N-甲基D-天冬氨酸(NMDA)受体的亲和力高,可达到与氯胺酮同样的麻醉效果,但剂量却大大减少,也因此减少了由于剂量依赖而产生的精神方面的不良影响。艾司氯胺酮在镇痛、抗抑郁、抗炎等方面均具有较强的作用,本文就其在临床麻醉中的应用进行综述。Ketamine,as the only anesthetic with an analgesic effect,was widely used in clinical practice.However,its application has been greatly reduced due to its apparent psychopathic adverse reactions.Esketamine,the right-handed enantiomer of ketamine,has emerged due to its high affinity for N-methyl-D-aspartate(NMDA)receptors,which can achieve the same anesthetic effect but with a significantly reduced dosage compared to ketamine.Consequently,it reduces the adverse psychotropic reactions caused by dose dependence.It has a strong effect on analgesia,anti-depression,anti-inflammatory and other aspects.This article reviews the application of esketamine in clinical anesthesia.

关 键 词：艾司氯胺酮 临床麻醉 术后认知功能 炎症反应 

分 类 号：R614[医药卫生—麻醉学]