脂代谢异常在胰腺癌发生发展中作用的研究进展  

Role of lipid metabolism disorders in the occurrence and development of pancreatic cancer:a review of research progress

作　　者：王云峰 夏俊伟 徐白莹 WANG Yunfeng;XIA Junwei;XU Baiying(Department of General Surgery,Pudong New Area People's Hospital,Shanghai 201299,China)

机构地区：[1]上海市浦东新区人民医院普通外科,上海201299

出　　处：《中国普通外科杂志》2024年第3期416-423,共8页China Journal of General Surgery

基　　金：上海市浦东新区卫生系统学科带头人培养计划基金资助项目(PWRd2021-16)。

摘　　要：大部分胰腺癌患者确诊时已经出现转移,手术治疗的机会少,化疗和放疗的治疗效果较差,目前急需新的治疗手段。脂代谢异常与胰腺癌发生发展的关系密切,脂代谢异常既是胰腺癌发生的危险因素,也能通过抑制胰腺癌细胞凋亡,增强胰腺癌细胞的代谢与增殖、转移等来加速胰腺癌的发展。笔者就脂代谢异常在胰腺癌相关的进展和关注点进行总结和论述,以期为相关研究提供参考。Most pancreatic cancer patients are diagnosed with metastasis already present,leaving few opportunities for surgical treatment,and chemotherapy and radiotherapy showing poor treatment outcomes.There is an urgent need for new treatment modalities.There is a close relationship between disorders of lipid metabolism and the occurrence and development of pancreatic cancer.Lipid metabolism disorders are not only risk factors for the development of pancreatic cancer but also accelerate the progression of pancreatic cancer by inhibiting apoptosis of pancreatic cancer cells and enhancing their metabolism,proliferation,and metastasis.Here,the authors summarize and discuss the progress and focal points of lipid metabolism disorders in pancreatic cancer,aiming to offer insights for relevant research.

关 键 词：胰腺肿瘤 脂代谢障碍 综述 

分 类 号：R654.3[医药卫生—外科学]