健康人鼻腔及鼻咽腔颗粒沉降的生物力学研究  

Biomechanical study of particle deposition in the nasal and nasopharyngeal cavities of healthy individual

作　　者：杨花 孙东 苏英锋 孙秀珍 于申[3] 唐媛媛 YANG Hua;SUN Dong;SU Yingfeng;SUN Xiuzhen;YU Shen;TANG Yuanyuan(Department of Otolaryngology,the Second Affiliated Hospital of Dalian Medical University,Dalian,Liaoning,116027,China;Department of Pediatric Otolaryngology,West China Second Hospital of Sichuan University,Chengdu,Sichuan,610041,China;State Key Aboratory of Structural Analysis for Industrial Equipment,Dalian University of Technology,Dalian,Liaoning,116023,China)

机构地区：[1]大连医科大学附属第二医院耳鼻咽喉科,辽宁大连116027 [2]四川大学华西第二医院小儿耳鼻咽喉科,四川成都610041 [3]大连理工大学工业装备结构分析国家重点实验室,辽宁大连116023

出　　处：《中国耳鼻咽喉头颈外科》2024年第3期161-166,共6页Chinese Archives of Otolaryngology-Head and Neck Surgery

基　　金：国家自然科学基金(81700874、11472074、12172082);大连医科大学附属第二医院院内培育项目(XJ2023000603)。

摘　　要：目的建立健康人鼻腔及鼻咽腔有限元数值模型,分析不同条件下鼻腔及鼻咽腔的颗粒沉降特征,从生物力学角度探讨颗粒沉降的影响因素,为临床鼻腔及鼻咽腔疾病的潜在诱发因素及经鼻腔给药方式提供参考。方法采集志愿者鼻部多层螺旋CT数据,重建上呼吸道三维数值模型后,针对不同气流流率、颗粒粒径及颗粒密度条件下的颗粒沉降进行数值模拟。结果鼻阈、鼻甲前端、鼻咽顶后壁为颗粒最易沉降区域。当气流流率为30 L/min及60 L/min时,不同颗粒直径、颗粒密度下该重建模型沉积率均可达80%以上。当颗粒粒径为10μm及15μm时,不同气流流率、颗粒密度下该重建模型沉积率均可达90%以上。结论(1)颗粒在鼻腔主要沉降于鼻阈及鼻前庭,在鼻咽腔则主要沉降于鼻咽顶后壁;(2)气流速度、颗粒粒径及密度对颗粒沉积率均有影响,其中颗粒粒径对颗粒沉降影响最大,其次是气流流率、颗粒密度;(3)当颗粒密度及气流流率不变,相较于10μm和15μm的颗粒,直径为5μm的颗粒在鼻咽部颗粒沉降最多。OBJECTIVE To establish a finite element numerical model of the nasal and nasopharyngeal cavities of healthy people,analyze the particle deposition characteristics of the nasal and nasopharyngeal cavities under different conditions,and explore the influencing factors of particle deposition from the biomechanical point of view,so as to provide a reference for the potential predisposing factors of clinical nasal and nasopharyngeal diseases and the way of transnasal drug delivery.METHODS The multilayer spiral CT data of the nose of volunteers were collected,and after reconstructing the threedimensional numerical model of the upper respiratory tract,numerical simulations of particle deposition were performed under different conditions of airflow rates,particle sizes and particle densities.RESULTS The threshold of the nose,the anterior end of the turbinate,and the posterior wall of the roof of the nasopharynx were the regions where particles were most likely to deposit.When the airflow rate was 30 L/min and 60 L/min,the deposition rate of the reconstructed model could reach more than 80%under different particle diameters and particle densities.When the particle size is 10μm and 15μm,the deposition rate of the reconstruction model can reach more than 90%under different airflow rates and particle densities.CONCLUSION 1.Particles in the nasal cavity mainly deposited in the nasal threshold and nasal vestibule,while in the nasopharyngeal cavity,they mainly deposited in the posterior wall of the nasopharyngeal roof;2.The airflow rate,particle size,and density all had an effect on the deposition rate of particles,with particle size having the greatest effect on particle deposition,followed by the airflow rate,and particle density;3.When the particle density and the airflow rate were unchanged,the deposition rate of the particles with the diameter of 5μm could reach 80%or more in the nasopharyngeal cavity,compared to that of particles with diameters of 10μm and 15μm,with different airflow rates and particle densities.

关 键 词：鼻腔 鼻咽 生物力学 颗粒沉降 

分 类 号：R318.01[医药卫生—生物医学工程]