梅尼埃病患者伴随常见变应性疾病的调查与分析  

Investigation and analysis of atopic disease in patients with Meniere's disease

作　　者：张祎[1] 郭苏影 刘博[1] ZHANG Yi;GUO Suying;LIU Bo(Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Key Laboratory of Otolaryngology Head and Neck Science,Ministry of Education(Capital Medical University),Beijing,100730,China)

机构地区：[1]首都医科大学附属北京同仁医院耳鼻咽喉头颈外科,北京市耳鼻咽喉科研究所,耳鼻咽喉头颈科学教育部重点实验室(首都医科大学),北京100730

出　　处：《中国耳鼻咽喉头颈外科》2024年第3期167-170,共4页Chinese Archives of Otolaryngology-Head and Neck Surgery

基　　金：北京同仁医院重点医学发展计划(trzkyxzy201802)。

摘　　要：目的调查梅尼埃病患者伴随的变应性疾病情况,分析其临床特点。方法通过前瞻性队列研究,连续纳入确诊的梅尼埃病患者152例作为病例组,纳入性别、年龄相匹配的社区随机抽取的非梅尼埃病志愿者100名作为对照组;通过问卷调查对存在的变应性因素进行分析研究。结果病例组比对照组伴随的变应性因素发生率高。(1)病例组中变应性鼻炎的患病率[28.29%(43/152)]高于对照组[16.00%(16/100)],差异具有统计学意义(χ^(2)=5.080,P=0.024);有病毒感染史的比例[50.00%(76/152)]高于对照组[33.33%(33/100)],差异具有统计学意义(χ^(2)=7.102,P=0.008);(2)病例组中偏头痛的患病率[37.50%(57/152)]高于对照组[22.00%(22/100)],差异具有统计学意义(χ^(2)=6.733,P=0.009),有偏头痛的梅尼埃病患者中伴随变应性疾病[56.14%(32/57)]和病毒感染史[66.67%(38/57)]的比例也较无偏头痛者比例高[32.63%(31/95)和40.00%(38/95)](χ^(2)=8.113,P=0.004;χ^(2)=10.133,P=0.001)。结论梅尼埃病患者伴随的变应性疾病发生率较高。有病毒感染史者占比较高的原因还应做进一步研究。OBJECTIVE To investigate the atopic factors of patients with Meniere's disease and explore the relationship of these factors with the characteristics of the patients.METHODS A prospectively descriptive study was conducted.One hundred and fifty-two patients with definite Meniere's disease were recruited into the study group;meanwhile,100 non-Meniere's disease volunteers were randomly selected from the community as the control group.The atopic factors were investigated and analyzed depending on the history.RESULTS Patients with Meniere's disease had a higher incidence of atopic factors than controls.1.The incidence of allergic rhinitis in patients with Meniere's disease[28.29%(43/152)]was higher than that in control[16%(16/100)](χ^(2)=5.080,P=0.024);The history of virus infection[50.00%(76/152)]was higher than that in the control group[33.33%(33/100)](χ^(2)=7.102,P=0.008);2.The incidence of migraine in Meniere's disease[37.50%(57/152)]was higher than that in the control group[22.00%(22/100)](χ^(2)=6.733,P=0.009),and the incidence rate of the patients with allergic factors[56.14%(32/57)](χ^(2)=8.113,P=0.004)or a history of virus infection[66.67%(38/57)](χ^(2)=10.133,P=0.001)was high.CONCLUSION Patients with Meniere's disease have a higher probability of atopic disease and a history of virus infection,especially in patients accompanied by migraines.

关 键 词：梅尼埃病 免疫 偏头痛 病毒 变应性疾病 

分 类 号：R764.33[医药卫生—耳鼻咽喉科]