Metal-based inorganic nanocrystals for biological sonodynamic therapy applications:recent progress and perspectives  

作　　者：Dong Wang Jia-Tao Zhang 

机构地区：[1]Institute of Medical-Industrial Integration,Beijing Key Laboratory of Structurally Controllable Advanced Functional Materials and Green Applications,School of Materials Science and Engineering,Beijing Institute of Technology,Beijing,100081,China [2]Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering,Ministry of Industry and Information Technology,School of Chemistry and Chemical Engineering,Beijing Institute of Technology,Beijing,100081,China

出　　处：《Rare Metals》2024年第2期413-430,共18页稀有金属（英文版）

基　　金：This study was financially supported by the National Natural Science Foundation of China(Nos.22105116,51872030,51631001,51702016,51902023 and 21801015);Joint R&D Plan of Hongkong,Macao,Taiwan and Beijing(No.Z191100001619002);the Fundamental Research Funds for the Central Universities(No.2017CX01003);Beijing Institute of Technology Research Fund Program for Young Scholars.

摘　　要：With the fast development of technology for the treatment of tumor and bacteria,photo-therapeutic strate-gies emerge as a kind of highly effective and common treatment,but the low tissue penetration depth of light limits their development.Sonodynamic therapy(SDT),as an efficient and non-invasive treatment,attracts more people's attention due to the inherent property of high tissue penetration.The soft tissue penetration depth of ultrasound(US)can even reach more than 10 cm,which has great advantage over that of light.Therefore,many sonosensitizers are studied and applied to SDT-based therapy.Metal-based inorganic nanocrystals are able to generate more reactive oxygen species(ROS)due to the special composition and band structure.The representative achievements and the specific functions of the nanocrystals sonosensitizers are summarized in this work,and the relationship of structure/composition-SDT performance and the internally regulated composite is revealed.Syner-gistic effects of SDT in combination with other therapeutic modalities are mainly highlighted.At the same time,the critical and potential issues and future perspectives are addressed.

关 键 词：Metal-based inorganic nanocrystals Sonodynamic therapy(SDT) Tumor treatment ANTIBACTERIA 

分 类 号：R318[医药卫生—生物医学工程] TB383.1[医药卫生—基础医学]