Curation,nomenclature,and topological classification of receptor-like kinases from 528 plant species for novel domain discovery and functional inference  

作　　者：Qian Liu Qiong Fu Yujie Yan Qian Jiang Longfei Mao Long Wang Feng Yu Heping Zheng 

机构地区：[1]State Key Laboratory of Chemo/Biosensing and Chemometrics,Hunan University College of Biology,Changsha,Hunan 410082,China [2]Bioinformatics Center,Hunan University College of Biology,Changsha,Hunan 410082,China

出　　处：《Molecular Plant》2024年第4期658-671,共14页分子植物（英文版）

基　　金：supported by startup funds provided by Hunan University;a database development fund provided by Suzhou Tributary Biologics Co.Ltd.,;grants supported by the National Key R&D Program of China(2023YFD1401100);the Natural Science Foundation of China(32070769,32370757,and 32201712);the Science and Technology Innovation Program of Hunan Province(2021JJ10015,2021JJ30101,2023JJ40131,and 2023ZJ1080).

摘　　要：Receptor-like kinases(RLKs)are the most numerous signal transduction components in plants and play important roles in determining how different plants adapt to their ecological environments.Research on RLKs has focused mainly on a small number of typical RLK members in a few model plants.There is an urgent need to study the composition,distribution,and evolution of RLKs at the holistic level to increase our understanding of how RLKs assist in the ecological adaptations of different plant species.In this study,we collected the genome assemblies of 528 plant species and constructed an RLK dataset.Using this dataset,we identified and characterized 524948 RLK family members.Each member underwent systematic topological classification and was assigned a gene ID based on a unified nomenclature system.Furthermore,we identified two novel extracellular domains in some RLKs,designated Xiao and Xiang.Evolutionary analysis of the RLK family revealed that the RLCK-XVII and RLCK-XII-2 classes were present exclusively in dicots,suggesting that diversification of RLKs between monocots and dicots may have led to differences in downstream cytoplasmic responses.We also used an interaction proteome to help empower data mining for inference of new RLK functions from a global perspective,with the ultimate goal of understanding how RLKs shape the adaptation of different plants to the environments/ecosystems.The assembled RLK dataset,together with annotations and analytical tools,forms an integrated foundation of multiomics data that is publicly accessible via the metaRLK web portal(http://metaRLK.biocloud.top).

关 键 词：RLK RLCK DOMAIN signaling pathway receptor-protein interactions 

分 类 号：Q94[生物学—植物学]