抗菌肽在猪精液常温保存中的应用研究进展  

Advances of the Application of Antimicrobial Peptides in the Preservation of Porcine Semen at Room Temperature

作　　者：黄杰 阮子豪 蔡瑞 HUANG Jie;RUAN Zihao;CAI Rui(Key Laboratory of Animal Genetics,Breeding and Reproduction of Shaanxi Province,College of Animal Science and Technology,Northwest A&F University,Yangling 712100,China)

机构地区：[1]西北农林科技大学动物科技学院陕西省动物遗传育种与繁殖重点实验室,杨凌712100

出　　处：《畜牧兽医学报》2024年第4期1401-1411,共11页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家重点研发计划项目(2021YFF1000602);陕西省自然科学基金项目(2022JQ-170);国家生猪产业技术体系(CARS-35-PIG)。

摘　　要：人工授精(AI)是畜牧业加速发展的核心技术之一,精液保存为其中的一个关键环节。猪精液在保存过程中容易受到细菌污染而导致精子质量下降,随着全面禁抗时代的到来,迫切需要开发具有不同活性的抗菌替代品,以提高精液保存效果。抗菌肽(AMPs)因具有广谱抗菌活性和较低耐药性,通过细胞膜损伤和非膜损伤机制在猪精液保存过程中发挥抗菌作用,目前已成为抗生素的重要替代品。本文综述了AMPs的抑菌机制及其在猪精液保存技术中应用的研究进展,旨在为猪精液常温保存抗菌肽产品的开发提供科学依据。Artificial insemination(AI)is one of the core technologies accelerating the development of animal husbandry.Semen preservation is a key part of AI.Porcine semen is susceptible to bacterial contamination during preservation leading to a decline in sperm quality.With the advent of the era of total antibiotic ban,there is an urgent need to develop antibacterial alternatives with different activities to improve the effect of semen preservation.Antimicrobial peptides(AMPs)have become an important substitute for antibiotics due to their broad-spectrum antimicrobial activity and lower drug resistance.AMPs play an antibacterial role in the preservation of porcine semen by exerting antibacterial effects through cell membrane damage and non-membrane damage mechanisms.This article reviews the research progress of AMPs′antibacterial mechanisms and their application in porcine semen preservation techniques.The aim is to provide a scientific basis for the development of antimicrobial peptide products preserved in porcine semen at room temperature.

关 键 词：猪 精液保存 抗菌肽 细菌污染 抑菌机制 

分 类 号：S828.3[农业科学—畜牧学]