中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值和中性粒细胞/单核细胞比值参考区间的建立  

Establishment of Reference Intervals for Ratios of Neutrophil/Lymphocyte,Platelet/Lymphocyte and Neutrophil/Monocyte

作　　者：何恩萍 李忠承 李静 段治军 全晖 HE Enping;LI Zhongcheng;DUAN Zhijun;QUAN Hui(Department of Clinical Laboratory,the Second Affiliated Hospital of Chengdu Medical College,Nuclear Industry 416 Hospital,Chengdu 610051,China)

机构地区：[1]成都医学院第二附属医院·核工业四一六医院检验科,四川成都610051

出　　处：《标记免疫分析与临床》2024年第3期464-467,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：目的建立成都地区中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)和中性粒细胞/单核细胞比值(NMR)的参考区间,为临床诊疗提供更充分的依据。方法收集2017年1月1日至2022年9月13日在核工业四一六医院体检且严格排除近期患有感染性疾病的查体人群的外周血标本(EDTA-K_(2)抗凝标本)1918例,采用第2.5百分位数(P_(2.5))~第97.5百分位数(P_(97.5))建立NLR、PLR和NMR的参考区间。结果NLR男性、女性参考区间差异有统计学意义(P<0.01),分别是0.88~3.53和0.89~4.67;PLR男性、女性参考区间差异有统计学意义(P<0.01),分别是40.35~170.47和51.04~188.64;NMR男性、女性参考区间差异具有统计学意义(P<0.01),分别是4.55~13.76与4.64~17.91。结论NLR、PLR和NMR参考区间的建立有助于临床对感染性疾病的诊断和鉴别诊断,也为联合其他感染性疾病标志物对特定疾病研究奠定了一定基础。Objective To establish the reference interval of neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR)and neutrophil-to-monocyte ratio(NMR)in Chengdu area,and to further provide more complete knowledge basis for clinical diagnosis and treatment.Methods From January 1,2017 to September 13,2022,1918 peripheral blood samples(EDTA-K_(2) anticoagulant samples)were collected from people who underwent physical examination in Nuclear Industry 416 Hospital and were strictly excluded from recent infectious diseases.The reference intervals of NLR,PLR and NMR were established by using the 2.5 percentile(P_(2.5))to 97.5 percentile(P_(97.5)).Results There was statistical significance in differences of NLR,PLR and NMR between male and female groups(P<0.01).The reference interval of NLR was 0.88-3.53 for male,and 0.89-4.67 for female.The reference interval of PLR was 40.35-170.47 for male,and 51.04-188.64 for female.The reference interval of NMR was 4.55-13.76 for male,and 4.64-17.91 foe female.Conclusion The establishment of reference intervals for NLR,PLR and NMR can facilitate the clinical diagnosis and differential diagnosis of infectious diseases,and it also lays a good foundation for the study of specific diseases in combination with other infectious disease markers.

关 键 词：中性粒细胞/淋巴细胞比值 血小板/淋巴细胞比值 中性粒细胞/单核细胞比值 感染标志物 参考区间 

分 类 号：R446[医药卫生—诊断学]