人工智能辅助外周血有核红细胞形态学分类  

Artificial Intelligence Assisted Morphological Classification of Nucleated Red Blood Cells in Peripheral Blood

作　　者：商蕾 李晨辉 刘雪凯[1] SHANG Lei;LI Chenhui;LIU Xuekai(Aerospace Center Hospital,Beijing 100049,China)

机构地区：[1]航天中心医院,北京100049

出　　处：《标记免疫分析与临床》2024年第3期534-538,共5页Labeled Immunoassays and Clinical Medicine

基　　金：北京市重大疫情防治重点专科项目(编号:京卫医[2021]135号)。

摘　　要：目的评估人工智能(AI)血细胞形态分析仪(AI阅片机)对外周血有核红细胞(NRBC)检测的性能。方法收集1191例静脉血标本(全自动血细胞分析仪报警提示有核红细胞),将静脉血分为3个组(NRBC绝对值低、中、高值),用AI阅片机检测NRBC%,将预分类结果与形态学专家审核后结果进行统计学分析。②收集494例静脉血标本(NRBC绝对值≥1×10^(9)/L),用AI阅片机进行外周血细胞形态学分类,由形态学专家对结果进行校正,制作血细胞分类混淆矩阵,分析AI阅片机对外周血细胞分类的符合度和检出率。结果AI阅片机对NRBC%检测结果与专家审核后结果差异无统计学意义(P<0.005),R^(2)>0.99;AI阅片机共检测出99137个NRBC,识别正确99031个,专家校正结果为99976个。AI阅片机对NRBC检出的符合率为99.89%,检出率为99.05%。结论AI阅片机对外周血中NRBC的检测结果与专家审核后结果的符合率和检出率均较高,为NRBC相关疾病的筛查提供了高效的辅助检测手段。Objective To evaluate the performance of artificial intelligence(AI)-based blood cell morphology analyzer(AI reader)in detecting peripheral blood nucleated red blood cells(NRBC).Methods We collected 1191 venous blood samples(automatic blood cell analyzer alarm indicating nucleated red blood cells)and then divided these samples into three groups:low-,medium-,and high-absolute NRBC values.AI reader was used to detect NRBC%,and statistical analysis was performed on the pre-classification results and the results were reviewed by morphological experts;We collected 494 venous blood samples(NRBC absolute value≥1×10^(9)/L),and classified peripheral blood cell morphology using an AI reader.We then corrected the results by morphological experts,and created a confusion matrix for blood cell classification,and evaluated the consistency and detection rate of the AI reader for peripheral blood cell classification.Results There was no statistically significant difference(P<0.05)between the NRBC%detection results of the AI film reader and the expert review results,with R^(2)>0.99.The AI film reader detected a total of 99137 NRBCs,in which 99031 sample were identified correctly,while the expert correction result was 99976.The compliance rate of the AI film reader for detecting NRBC was 99.89%,and the detection rate was 99.05%.Conclusion The AI film reader shows a high consistency and detection rate between the detection results of NRBC in peripheral blood and the results reviewed by experts,providing an efficient auxiliary detection method for screening NRBC related diseases.

关 键 词：人工智能(AI) 有核红细胞 NRBC 

分 类 号：R446[医药卫生—诊断学] TP18[医药卫生—临床医学]