肌联素与糖尿病胰岛素抵抗关系的研究进展  

Research progress on the relationship between myoglobin and insulin resistance in diabetes mellitus

作　　者：杨卡明 毕长龙 YANG Kaming;BI Changlong(Department of Endocrinology,The Eighth Affiliated Hospital,Sun Yat-sen University,Shenzhen 518033,China)

机构地区：[1]中山大学附属第八医院内分泌科,广东深圳518033

出　　处：《老年医学研究》2024年第2期47-51,共5页Geriatrics Research

基　　金：国家自然科学基金面上项目(82172215,HDAC4调控MEKK2/MAPK信号通路延缓DFU创面愈合的机制研究);广东省基础与应用基础研究基金(2021A1515012109,HDAC4调控成纤维细胞自噬影响糖尿病足溃疡创面愈合的机制研究);深圳市福田区卫生健康系统科研项目(FTWS2023008,温敏性羟丁基壳聚糖水凝胶联合人表皮生长因子对糖尿病足创面愈合的干预性临床研究)。

摘　　要：全球范围内,2型糖尿病患者数量逐年上升,胰岛素抵抗和胰岛β细胞功能不全是2型糖尿病的主要病理生理因素。骨骼肌作为胰岛素抵抗的重要靶组织,能够分泌多种肌肉因子参与机体生理活动。肌联素是一种肌肉因子,研究发现,肌联素通过脂肪组织参与葡萄糖和脂质代谢调控,与2型糖尿病胰岛素抵抗密切相关。本文旨在综述肌联素与糖尿病胰岛素抵抗关系方面的研究概况,深入探究肌联素与胰岛素抵抗以及2型糖尿病的发生和发展之间的关系。The prevalence of Type 2 Diabetes Mellitus(T2DM)is steadily increasing worldwide.Insulin resistance and pancreatic β-cell dysfunction are the primary pathophysiological factors contributing to the development of T2DM.Skeletal muscle,a key target tissue for insulin resistance,plays a significant role in the secretion of various myokines involved in physiological processes.Myonectin,one such myokine,has been identified to participate in the regulation of glucose and lipid metabolism through adipose tissue,thereby closely associated with insulin resistance in T2DM.This review aims to provide an overview of the relationship between myonectin and insulin resistance in T2DM,and thoroughly explore the intricate relationship between myonectin and the development of insulin resistance and T2DM.

关 键 词：糖尿病 胰岛素抵抗 肌联素 

分 类 号：R587.1[医药卫生—内分泌]