AMPA与NMDA抗体重叠的自身免疫性脑炎合并眼阵挛-肌阵挛综合征1例报告  

A case report of anti-NMDAR and anti-AMPAR autoimmune encephalitis with opsoclonus-myoclonus syndrome

作　　者：江佳佳 杨伊 王文暄 刘雅菁 尹梓曈 冯双浩 李小艳 卜晖[1] JIANG Jiajia;YANG Yi;WANG Wenxuan(Department of Neurology,The Second Hospital of Hebei Medical University,Shijiazhuang 050004,China)

机构地区：[1]河北医科大学第二医院,河北石家庄050004

出　　处：《中风与神经疾病杂志》2024年第4期369-371,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：眼阵挛-肌阵挛综合征(OMS)是一种少见的神经系统综合征,与肿瘤相关,常见于儿童,成人少见,其特征是不自主、无节律、混乱、多向的眼球不自主运动,通常伴有四肢和躯干肌阵挛性抽搐、共济失调。抗α-氨基-3-羟基-5-甲基-4-异唑丙酸受体(AMPAR)与抗N-甲基-D-天冬氨酸受体(NMDAR)抗体重叠的自身免疫性脑炎合并眼阵挛-肌阵挛综合征的病例报道更为少见,对其临床表现及治疗缺乏全面的认识。现报道1例AMPAR与NMDAR抗体重叠的自身免疫性脑炎合并眼阵挛-肌阵挛综合征患者,并基于此病例对国内外相关文献进行复习,以期提高临床医生的认识。Opsoclonus-myoclonus syndrome(OMS)is a rare neurological syndrome associated with tumors,which is more common in children than in adults.It is characterized by involuntary,arrhythmic,chaotic,multidirectional saccades,usually accompanied by limb and trunk myoclonic seizures and ataxia.Case reports are even rare on OMS complicated by autoimmune encephalitis with overlapping antibodies against the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor(AMPAR)and N-methyl-D-aspartate receptor(NMDAR),and its clinical manifestations and treatment are poorly understood.We report a case of autoimmune encephalitis with OMS positive for both NMDAR and AMPAR antibodies,and also review relevant literature to help improve the understanding of the condition.

关 键 词：自身免疫性脑炎 α-氨基-3-羟基-5-甲基-4-异唑丙酸 N-甲基-D-天冬氨酸 边缘性脑炎 重叠综合征 眼阵挛-肌阵挛综合征 

分 类 号：R512.3[医药卫生—内科学]