董昌盛运用芳香类中药治疗肺结节规律  

Regularity of Dong Changsheng’s Application of Aromatic Traditional Chinese Medicine in the Treatment of Pulmonary Nodules

作　　者：孙修桥 伍睿昕[2] 楚晓 符达 马雨水 张继亮 韩睿钦 董昌盛 SUN Xiuqiao;WU Ruixin;CHU Xiao;FU Da;MA Yushui;ZHANG Jiliang;HAN Ruiqin;DONG Changsheng(Cancer Institute of Traditional Chinese Medicine,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Preclinical Department,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China;Department of Thoracic Surgery,Shanghai Fifth People’s Hospital,Fudan University,Shanghai 200240,China;Pancreatic Center of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Beijing Tong Ren Tang Chinese Medicine Co.,Ltd.,Hong Kong 999077,China;State Key Laboratory of Common Mechanism Research for Major Disease,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100005,China;Department of Oncology,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院中医肿瘤研究所,上海200032 [2]上海中医药大学附属上海市中医医院治未病科,上海200071 [3]复旦大学附属上海市第五人民医院胸外科,上海200240 [4]上海交通大学医学院附属瑞金医院胰腺中心,上海200025 [5]北京同仁堂国药有限公司,中国香港999077 [6]中国医学科学院基础医学科学研究所重大疾病共性机制研究全国重点实验室,北京100005 [7]上海中医药大学附属龙华医院肿瘤科,上海200032

出　　处：《香料香精化妆品》2024年第2期34-40,共7页Flavour Fragrance Cosmetics

基　　金：国家重点研发计划(编号2023YFC3503201);国家自然科学基金项目(编号81403356);上海市科委“科技创新行动计划”生物医药科技支撑专项(编号20S31904100);上海市卫生健康委卫生行业临床研究专项(编号202040155);上海中医药大学杏林青年学者培养计划(编号RC-2017-02-02)。

摘　　要：通过运用R语言分析了2017年1月1日至2023年11月30日于上海中医药大学附属龙华医院董昌盛专家门诊收集、筛选到的治疗肺结节的中药处方,得到了处方583首,其中使用芳香类中药92味,使用频次前3的芳香类中药为当归、川芎、川牛膝;关联规则分析得到以柴胡、人参、肉桂为核心的芳香药物组合;聚类分析得到以枳术汤和四物汤为主的核心处方;相关性分析得出大枣-干姜、连翘-神曲等关联性药对。结果表明芳香类中药在肺结节的治疗中应用广泛,体现了董昌盛医师调元解毒、芳香化湿的治疗原则,为芳香类中药的运用拓展提供借鉴和参考。Using R language to analyze the traditional Chinese medicine prescriptions for the treatment of pulmonary nodules collected and screened from January 1,2017 to November 30,2023 at Dong Changsheng Expert Clinic of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine.583 prescriptions were obtained,using 92 aromatic traditional Chinese medicines.The top 3 aromatic traditional Chinese medicines with the highest frequency of use were Angelica sinensis,Ligusticum chanxiong Hort,and Cyathula officinalis kuan;The association rule analysis obtained a combination of aromatic drugs with Radix bupleuri,Panas sinserg,and Cinnamon cassia as the core;Cluster analysis revealed that the core prescriptions were mainly Zhizhu Tang and Siwu Tang;Correlation analysis showed that there were correlated drug pairs such as jujube dried ginger and Forsythia suspensa-Shenqu.The results indicate that aromatic traditional Chinese medicine is widely used in the treatment of pulmonary nodules,reflecting Dr.Dong Changsheng’s treatment principles of regulating energy,detoxifying,and aromatizing dampness,providing reference and guidance for the expansion of the use of aromatic drugs.

关 键 词：董昌盛 芳香类中药 肺结节 用药规律 数据挖掘 

分 类 号：R259[医药卫生—中西医结合] R249[医药卫生—中医内科学]