鼠神经生长因子联合rt-PA治疗急性脑梗死的疗效及对血清ET-1、TXA2水平的影响  

Efficacy of Mouse Nerve Growth Factor Combined with rt-PA in the Treatment of Acute Cerebral Infarction and Its Effect on Serum ET-1 and TXA2 Levels

作　　者：张晋源 梁花敏[1] 马薇[1] ZHANG Jin-yuan;LIANG Hua-min;MA Wei(General Hospital of Ningxia Medical University,Yinchuan,750000,China)

机构地区：[1]宁夏医科大学总医院神经内科,银川750000

出　　处：《神经药理学报》2023年第6期1-5,共5页Acta Neuropharmacologica

基　　金：宁夏医科大学校级科研项目(No.XM2021017)。

摘　　要：目的:探讨急性脑梗死(acute cerebral infarction,ACI)患者使用鼠神经生长因子(mouse nerve growth factor,mNGF)联合阿替普酶(alteplase,rt-PA)治疗的临床效果。方法:ACI患者80例随机分为对照组(40例)与观察组(40例)。对照组予以rt-PA溶栓治疗,观察组在rt-PA溶栓治疗基础上联合mNGF治疗,两组均治疗14 d。分别于治疗前和治疗后,使用美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评估患者神经功能,使用Barthel指数(Barthel Index,BI)评估患者日常生活能力,并进行血清C反应蛋白(c-reactive protein,CRP)、血沉(erythrocyte sedimentation rate,ESR)、内皮素-1(endothelin-1,ET-1)和血栓素A2(thromboxane A2,TXA2)的检测。比较两组各项指标差异和不良反应,并统计两组不良反应发生率。结果:两组总有效率对比,观察组(95.00%)高于对照组(80.00%),差异显著(P<0.05)。治疗后,与对照组相比,观察组NIHSS评分更低(P<0.05),BI评分更高(P<0.05),血清CRP、ESR、ET-1和TXA2水平显著下降(P<0.05)。两组不良反应发生率不具有统计学差异(P>0.05)。结论:mNGF联合rt-PA治疗ACI可提高疗效,促进患者神经功能恢复,降低血清ET-1、TXA2水平。Objective:To investigate the clinical effect of mouse nerve growth factor(mNGF)combined with alteplase(rt-PA)in patients with acute cerebral infarction(ACI).Methods:A total of 80 ACI patients were randomly divided into control group(40 cases)and observation group(40 cases).The control group was treated with rt-PA thrombolytic therapy,and the observation group was treated with mNGF on the basis of rt-PA thrombolytic therapy.Both groups were treated for 14 days.Before and after treatment,the National Institutes of Health Stroke Scale(NIHSS)was used to evaluate the neurological function of the patients,the Barthel Index(BI)was used to evaluate the daily living ability of the patients,and the serum C-reactive protein(CRP),erythrocyte sedimentation rate(ESR)and endothelin-1(ET-1)and thromboxane A2(TXA2)were detected.The differences in indicators and adverse reactions between the two groups were compared,and the incidence of adverse reactions in the two groups was counted.Results:Compared the total effective rate of the two groups,the observation group(95.00%)was higher than the control group(80.00%),and the difference was significant(P<0.05).After treatment,compared with the control group,the NIHSS score was lower and the BI score was higher in the observation group(P<0.05).The levels of serum CRP,ESR,ET-1 and TXA2 in the observation group were also significantly decreased(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:mNGF combined with rt-PA in the treatment of ACI can improve the curative effect,promote the recovery of neurological function,and reduce the levels of serum ET-1 and TXA2.

关 键 词：急性脑梗死 鼠神经生长因子 阿替普酶 神经功能 内皮素-1 血栓素A2 

分 类 号：R969[医药卫生—药理学]