药食同源背景下白藜芦醇的镇痛作用研究  

Study on the Analgesic Effect of Resveratrol in the Context of Pharmacognosy

作　　者：陈衍铭 陈劲松 CHEN Yan-ming;CHEN Jin-song(Peking University Health Science Center,Beijing,100000,China;Xuzhou Food and Drug Supervision and Inspection Center,Xuzhou,221000,China)

机构地区：[1]北京大学医学部,北京100000 [2]徐州市食品药品监督检验中心,徐州221000

出　　处：《神经药理学报》2023年第6期6-11,共6页Acta Neuropharmacologica

摘　　要：目的:药食同源产业是国家发展“健康中国”战略中不可或缺的一环。白藜芦醇是一种天然活性化合物,已被证实在炎症、心脏病、癌症等多种疾病中有生物活性。本研究旨在探讨白藜芦醇在小鼠急慢性疼痛中的镇痛作用。方法:本研究通过构建小鼠急性疼痛模型(醋酸致小鼠扭体模型、福尔马林致持续性疼痛模型)和慢性疼痛模型(紫杉醇诱导的神经病理性疼痛),对白藜芦醇的镇痛作用进行了评估。结果:行为学结果表明,白藜芦醇能有效减轻小鼠急慢性疼痛行为并表现出有益效果。结论:因此,白藜芦醇可能成为治疗小鼠急慢性疼痛的潜在药物。本研究为后续相关研究提供一定的理论基础,并为临床安全有效镇痛提供新的思路和方法。Objective:The food and medicine industry is an integral part of the national strategy to develop a“healthy China”.Resveratrol is a naturally occurring compound that has been shown to be biologically active in various diseases such as inflammation,heart disease and cancer.The aim of this study was to investigate the analgesic effects of resveratrol in acute and chronic pain in mice.Methods:In this study,the analgesic effects of resveratrol were evaluated by constructing mouse models of acute pain(acetic acid-induced torsion,formalin-induced persistent pain)and chronic pain(paclitaxel-induced neuropathic pain).Results:The behavioural results showed that resveratrol was effective in reducing acute and chronic pain behaviour in mice and exhibited beneficial effects.Conclusion:Therefore,resveratrol may be a potential drug for the treatment of acute and chronic pain in mice.This study provides a certain theoretical basis for subsequent related studies and offers new ideas and methods for safe and effective clinical analgesia.

关 键 词：白藜芦醇 镇痛作用 小鼠 急慢性疼痛 

分 类 号：R965[医药卫生—药理学]