乙癸愈风汤联合针灸对缺血性脑卒中患者疗效及炎症因子水平影响的分析  

Analysis of the Effect of Yigui Yufeng Decoction Combined with Acupuncture on the Curative Effect and Inflammatory Factor Level of Ischemic Strok

作　　者：赵汉清[1] 冯鹏超 周利飞 李丽[3] ZHAO Han-qing;FENG Peng-chao;ZHOU Li-fei;LI Li(Department of Traditional Chinese Medicine,Second Affiliated Hospital of Hebei North University,Zhangjiakou,075100,China;Department of Neurology,Second Affiliated Hospital of Hebei North University,Zhangjiakou,075100,China;Department of Pharmacy,Second Affiliated Hospital of Hebei North University,Zhangjiakou,075100,China)

机构地区：[1]河北北方学院附属第二医院中医科,张家口075100 [2]河北北方学院附属第二医院神经科,张家口075100 [3]河北北方学院附属第二医院药剂科,张家口075100

出　　处：《神经药理学报》2023年第6期12-15,共4页Acta Neuropharmacologica

基　　金：河北省重点研发计划自筹项目(No.182777220)。

摘　　要：目的:探讨乙癸愈风汤联合针灸对缺血性脑卒中患者的临床疗效及其对炎症因子水平的影响。方法:选取82例缺血性脑卒中患者按随机数字表法分为治疗组和对照组各41例,对照组给予常规西医治疗,治疗组在对照组治疗基础上给予乙癸愈风汤及针灸治疗,14 d为1个疗程。1个疗程后观察疗效及治疗前后血清超敏-C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、血同型半胱氨酸(homocysteine,Hcy)、及D-二聚体水平,比较治疗前后患者日常生活活动能力量表(activity of daily living,ADL)及美国国立卫生院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分。结果:治疗1个疗程后,治疗组临床疗效有效率(92.68%)高于对照组为(73.17%),差异有统计学意义(P<0.05);治疗前2组患者血清hs-CRP、Hcy、D-二聚体水平差异无统计学意义(P>0.05),治疗后治疗组患者上述因子水平均低于对照组(P<0.05);治疗前2组患者ADL及NIHSS量表评分差异无统计学意义(P>0.05),治疗后治疗组患者ADL评分高于对照组且NIHSS评分低于对照组(P<0.05);结论:乙癸愈风汤联合针灸辅助治疗缺血性脑卒中疗效良好,较单纯常规西医治疗能够显著改善患者临床症状,降低炎症因子水平,提高患者生活质量及神经功能。Objective:To investigate the clinical efficacy of Yigui Yufeng Decoction in patients with ischemic stroke and its effect on the level of inflammatory factors.Methods:82 patients with ischemic stroke were randomly divided into treatment group and control group,41 cases in each group.The control group was treated with conventional western medicine,and the treatment group was treated with Yigui Yufeng Decoction and acupuncture on the basis of the control group.The treatment time of the two groups was 14 days.The effective rate of treatment and the levels of serum high-sensitivity C-reactive protein(hs-CRP),blood homocysteine(Hcy)and D-dimer before and after treatment were compared between the two groups.The activities of daily living scale(ADL score)and NIHSS scale score were compared between the two groups before and after intervention.Results:After 14 days of treatment,the effective rate of the treatment group was(92.68%),and that of the control group was(73.17%).The difference was statistically significant(P<0.05).After treatment,the levels of the above factors in the treatment group were lower than those in the control group(P<0.05).After treatment,the ADL score of the treatment group was higher than that of the control group,and the NIHSS score was lower than that of the control group(P<0.05).Conclusion:Yigui Yufeng Decoction combined with acupuncture has a good therapeutic effect on patients with ischemic stroke.It can significantly improve the clinical symptoms of patients,reduce the level of inflammatory factors in the body,and improve the quality of life and neurological function of patients.

关 键 词：乙癸愈风汤 针灸 缺血性脑卒中 神经元损伤 

分 类 号：R969[医药卫生—药理学]