经筋微创痛风石切除术联合枸橼酸氢钾钠应用于巨大痛风石患者中的效果及对神经体液的影响研究  

Study on the Effect and Neurohumoral Effect of Minimally Invasive Gastritis Resection Combined with Potassium Sodium Hydrogen Citrate in Patients with Giant Gastritis

作　　者：杨富松 杨洋[1] 王忠波 曾颖洁 郭航 YANG Fu-song;YANG Yang;WANG Zhong-bo;ZENG Ying-Jie;GUO Hang(Department of General Medicine,Anning First People's Hospital Affiliated to Kunming University of Science and Technology,Anning,650300,China;Department of Geriatrics,Lufeng People's Hospital,Lufeng,651200,China;Department of Medical Imaging,Jinfang Branch,Anning First People's Hospital,Anning,650300,China;Department of Geriatrics,Mengzi People's Hospital,Mengzi,661100,China)

机构地区：[1]昆明理工大学附属安宁市第一人民医院全科医学科,安宁650300 [2]禄丰市人民医院老年医学科,禄丰651200 [3]安宁市第一人民医院人民医院医学影像科,安宁650300 [4]蒙自市人民医院老年医学科,蒙自661100

出　　处：《神经药理学报》2023年第6期31-35,共5页Acta Neuropharmacologica

摘　　要：目的:研究经筋微创痛风石切除术联合枸橼酸氢钾钠应用于巨大痛风石患者中的效果及对神经体液的影响。方法:选取安宁市第一人民医院从2020年11月~2022年4月收治的213例巨大痛风石患者作为研究对象。将其以电脑编号奇偶数字法随机分作研究组(n=107)及对照组(n=106)。对照组选用传统手术联合枸橼酸氢钾钠治疗,研究组则选用经筋微创痛风石切除术联合枸橼酸氢钾钠治疗。对比两组疗效,疼痛程度及关节功能,肾功能指标水平,神经体液因子水平。结果:研究组治疗总有效率高于对照组(97.19%vs 86.79%,P<0.05)。术后两组视觉模拟评分法(visual analogue scale,VAS)评分均低于术前,而美国特种外科医院(Hospital for Special Surgery,HSS)评分均高于术前;且研究组VAS评分低于对照组,而HSS评分高于对照组(均P<0.05)。术后两组各项肾功能指标水平均低于术前,且研究组低于对照组(均P<0.05)。术后两组各项神经体液因子水平均高于术前,但研究组低于对照组(均P<0.05)。结论:经筋微创痛风石切除术联合枸橼酸氢钾钠治疗巨大痛风石的效果较佳,可有效改善患者疼痛程度、关节功能、肾功能及神经体液因子水平。Objective:To study the effect of minimally invasive gastritis resection combined with potassium sodium hydrogen citrate in patients with giant gastritis and its influence on neurofluid.Methods:213 patients with giant gouty stones admitted to the First People's Hospital of Anning City from November 2020 to April 2022 were selected as the study objects.They were randomly divided into study group(n=107)and control group(n=106)by computer numbered odd-even number method.The control group was treated with traditional surgery combined with potassium sodium hydrogen citrate.In the study group,minimally invasive gastritis resection combined with potassium sodium hydrogen citrate was selected.The efficacy,pain degree,joint function,renal function index and neurohumoral factor level were compared between the two groups.Results:The total effective rate of the study group was higher than that of the control group(97.19%vs 86.79%)(P<0.05).The visual analogue scale(VAS)scores of both groups were lower than those before surgery,but the Hospital for Special Surgery(HSS)scores were higher than those before surgery.The VAS score of the study group was lower than that of the control group,and the HSS score was higher than that of the control group(all P<0.05).The levels of renal function indexes in both groups were lower after operation,and the study group was lower than the control group(all P<0.05).The levels of neurohumoral factors in the two groups were higher than those before surgery,but those in the study group were lower than those in the control group(all P<0.05).Conclusion:The effect of minimally invasive gastritis resection combined with potassium sodium hydrogen citrate in the treatment of giant gastritis is better,which can effectively improve the pain degree,joint function,kidney function and neurohumoral factor level of patients.

关 键 词：巨大痛风石 经筋微创痛风石切除术 枸橼酸氢钾钠 效果 神经体液 

分 类 号：R969[医药卫生—药理学]