疫苗佐剂的作用机制及研究进展  

Mechanism of Action of Vaccine Adjuvants and Research Progress

作　　者：张欣妍 石晓姿 赵永明[1] ZHANG Xin-yan;SHI Xiao-zi;ZHAO Yong-ming(Department of Pharmacy,Hebei North University,Hebei Key Laboratory of Neuropharmacology,Zhangjiakou,075000,China)

机构地区：[1]河北北方学院药学院,河北省神经药理学重点实验室,张家口075000

出　　处：《神经药理学报》2023年第6期55-64,共10页Acta Neuropharmacologica

基　　金：河北省医学科学研究课题计划项目(No.20230217)。

摘　　要：接种疫苗是目前预防传染性疾病最为经济有效的方法。佐剂是为了提高抗原免疫原性而添加到疫苗当中的物质,适宜比例佐剂的加入可以更好地辅助疫苗刺激机体,达到高效持久的免疫应答,降低疫苗的生产成本和药物的使用剂量,减少药物进入人体中产生的毒副作用。该文就常用佐剂及其免疫应答性质方面作一综述。以期为设计与选择安全有效的疫苗佐剂提供参考。Vaccination is currently the most economically effective method for preventing infectious diseases.Adjuvants are substances added to vaccines to enhance antigens immunogenicity.The appropriate addition of adjuvants can better assist vaccines in stimulating the body,achieving efficient and long-lasting immune responses,reducing the production costs of vaccines,and minimizing the dosage of drugs,thus decreasing the toxic side effects of drugs entering the human body.This article provides a comprehensive review of commonly used adjuvants and their immunogenic properties.It aims to serve as a reference for the design and selection of safe and effective vaccine adjuvants.

关 键 词：疫苗 佐剂 免疫 

分 类 号：R963[医药卫生—微生物与生化药学]