NKG2A-HLA-E轴介导NK细胞应答在病毒感染性疾病中的作用及机制研究进展  

Advances in the role and mechanism of NK cell immune response mediated by NKG2A-HLA-E axis in viral infectious diseases

作　　者：薛鳗玲 许晓悦 张希越 唐康 张宇丝 张春梅 庄然 金伯泉 张赟 岳昌武 马樱 XUE Manling;XU Xiaoyue;ZHANG Xiyue;TANG Kang;ZHANG Yusi;ZHANG Chunmei;ZHUANG Ran;JIN Boquan;ZHANG Yun;YUE Changwu;MA Ying(Medical school of Yan’an university,Yan’an 716000;Department of Immunology,Basic Medical Science Academy,Fourth Military Medical University,Xi’an 710032,China)

机构地区：[1]延安大学医学院,陕西延安716000 [2]空军军医大学基础医学院免疫学教研室,陕西西安710032

出　　处：《细胞与分子免疫学杂志》2024年第3期273-278,共6页Chinese Journal of Cellular and Molecular Immunology

基　　金：陕西省自然科学基础研究计划重点项目(2023-JC-ZD-49);国家自然科学基金(81871239)。

摘　　要：自然杀伤(NK)细胞主要通过迅速释放细胞毒性介质以及细胞因子直接杀伤病毒感染的靶细胞。NK细胞表面抑制性和活化性受体的平衡以及靶细胞上相应配体的表达均参与调控NK细胞的杀伤功能。其中NK细胞2组成员A(NKG2A)是NK细胞上备受关注的抑制性受体之一,通过与其配体人类白细胞抗原E(HLA-E)的相互作用,可抑制NK细胞对自身正常组织细胞的杀伤活性。研究发现病毒感染细胞表面HLA-E表达上调,并且可与病毒蛋白来源的多肽结合形成复合物,通过与NKG2A的相互作用调控NK细胞功能,从而参与病毒感染性疾病发病过程。本文总结了NKG2A与HLA-E分子互作特点,以及NKG2A-HLA-E轴参与调控NK细胞的功能机制,有助于了解NK细胞在病毒感染性疾病中的重要作用。Natural killer(NK)cells directly lysis the virus-infected cells through rapidly releasing cytotoxic mediators and cytokines.The balance between inhibitory and activated receptors on the surface of NK cells,as well as the corresponding ligands expressed on target cells are involved in the regulation of the cytotoxic function of NK cells.NKG2A is one of the highly anticipated inhibitory receptors expressed on NK cells,which can inhibit the cytotoxicity of NK cells to autologous normal tissue cells through interacting with the ligand HLA-E.The studies have shown that HLA-E is overexpressed on virus-infected cells and forms a complex with peptides derived from viral proteins.The interaction of HLA-E and NKG2A can regulate the functions of NK cells,participateing the pathogenesis process of virus infectious diseases.This review outlines the characteristics of the molecular interaction between NKG2A and HLA-E,as well as the mechanisms of NKG2A-HLA-E axis in regulating NK cell responses.

关 键 词：自然杀伤细胞2组成员A(NKG2A) 人类白细胞抗原E(HLA-E) 自然杀伤(NK)细胞 病毒感染性疾病 综述 

分 类 号：R511[医药卫生—内科学] R392.12[医药卫生—临床医学] G353.11[文化科学—情报学]