丝氨酸代谢在胶质瘤中的研究进展  

Research progress on serine metabolism in gliomas

作　　者：奥格斯·阿力甫 刘宏毅[1] 赵梦洁 肖红[2] Aogesi Alifu;LIU Hongyi;ZHAO Mengjie(Department of Neurosurgery,the Affiliated Brain Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学附属脑科医院神经外科,南京210029 [2]南京医科大学附属脑科医院研究所,南京210029

出　　处：《临床神经外科杂志》2024年第2期216-219,共4页Journal of Clinical Neurosurgery

基　　金：国家自然科学基金资助项目(81972350)。

摘　　要：神经胶质瘤是颅内常见恶性肿瘤,治疗难度大,且预后不佳。因此,胶质瘤的致病机制和治疗策略的研究是当前神经肿瘤领域的热点。丝氨酸是一种重要的非必需氨基酸,不仅为细胞内蛋白质、核酸和脂质的合成提供必要的前体,还可以为肿瘤细胞中氧化还原稳态的维持提供还原力,在细胞的生理和病理过程中发挥重要作用。近年来,有研究发现丝氨酸代谢与神经胶质瘤发展过程密切相关。本文旨在对丝氨酸在胶质瘤进展中的作用、潜在机制以及治疗策略做一综述。Glioma is a common malignant tumor within the cranium,presenting significant challenges in treatment and poor prognosis.Consequently,the investigation of the pathogenic mechanisms and therapeutic strategies for glioma represents a current focal point within the field of neuro-oncology.Serine is a critical non-essential amino acid,not only providing essential precursors for the synthesis of intracellular proteins,nucleic acids,and lipids,but also contributing to the maintenance of the redox homeostasis within tumor cells,playing a crucial role in the physiological and pathological processes of cells.In recent years,research has found a close association between serine metabolism and the development of glioma.This review aims to provide an overview of the role of serine in the progression of glioma,its potential mechanisms,and therapeutic.

关 键 词：丝氨酸代谢 神经胶质瘤 磷酸甘油酸脱氢酶 磷酸丝氨酸转氨酶1 磷酸丝氨酸磷酸酶 

分 类 号：R651[医药卫生—外科学]