PDDA-RGO/GCE电化学传感器检测阿司匹林  

PDDA-RGO/GCE Electrochemical Sensor for the Detection of Aspirin

作　　者：朱航 许桂芬 傅贤明 ZHU Hang;XU Guifen;FU Xianming(School of Pharmacy and Medical Technology,Putian University,Putian Fujian 351100,China;Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine(Putian University),Putian Fujian 351100,China)

机构地区：[1]莆田学院药学与医学技术学院,福建莆田351100 [2]药物分析与检验医学福建省高校重点实验室(莆田学院),福建莆田351100

出　　处：《莆田学院学报》2024年第2期57-61,90,共6页Journal of putian University

基　　金：福建省教育厅中青年教师教育科研项目(JT180489);莆田学院校内科研创新专项基金(2017020)。

摘　　要：通过简单的一步水热法,以尿素为还原剂,以聚二烯丙基二甲基氯化铵(PDDA)为改性剂,合成PDDA改性还原氧化石墨烯(PDDA-RGO)纳米复合材料。采用扫描电子显微镜、透射电子显微镜、紫外和红外等技术对合成的PDDA-RGO进行结构表征。使用合成的PDDA-RGO修饰玻碳电极制备电化学传感器,用于检测阿司匹林(ASP)的浓度,检测范围为5~2000μmol·L^(-1),线性方程为I=0.2487 c(ASP)+6.4128,线性相关系数R^(2)=0.9964,检测限为1.18μmol·L^(-1),空白加标回收率为99.4%~101.7%。结果表明,制备的传感器可以成功地应用于检测样品中阿司匹林的含量。This experiment synthesized polydiallyldimethylammonium chloride(PDDA)modified graphene(PDDA-RGO)nanocomposites by a simple one-step hydrothermal method using urea as a reducing agent and poly diallyl dimethyl ammonium chloride(PDDA)as a modifier.The structure of the synthesized PDDA-RGO was characterized by scanning electron microscopy,transmission electron microscopy,ultraviolet(UV),infrared(IR),and other techniques.An electrochemical sensor based on pdda-rgo modified glassy carbon electrode was prepared to detect Aspirin concentration at 5~2000μmol·L^(-1).The linear equation is I=0.2487 c(ASP)+6.4128,correlation linear coefficient R^(2)=0.9964,detection limit 1.18μmol·L^(-1).The ranges of blank spiking recovery rate are from 99.4%to 101.7%.The results indicate that the sensor can be successfully applied to detect the content of aspirin in samples.

关 键 词：聚二烯丙基二甲基氯化铵 改性 还原氧化石墨烯 阿司匹林 电化学 传感器 

分 类 号：R917[医药卫生—药物分析学]