Comparative transcriptomic evidence of physiological changes and potential relationships in vertebrates under different dormancy states  

作　　者：Yu-Han Niu Li-Hong Guan Cheng Wang Hai-Feng Jiang Guo-Gang Li Lian-Dong Yang Shun-Ping He 

机构地区：[1]State Key Laboratory of Freshwater Ecology and Biotechnology,Institute of Hydrobiology,Chinese Academy of Sciences,Wuhan,Hubei 430072,China [2]College of Life Sciences,Qinghai Normal University,Xining,Qinghai 810008,China [3]Academy of Plateau Science and Sustainability,Qinghai Normal University,Xining,Qinghai 810016,China [4]Key Laboratory of Biodiversity Formation Mechanism and Comprehensive Utilization of the Qinghai-Tibet Plateau in Qinghai Province,Qinghai Normal University,Xining,Qinghai 810008,China [5]College of Life Sciences and Technology,Xinxiang Medical University,Xinxiang,Henan 453003,China [6]College of Animal Science and Technology,Northwest A&F University,Yangling,Shaanxi 712100,China

出　　处：《Zoological Research》2024年第2期341-354,共14页动物学研究（英文）

基　　金：supported by the National Natural Science Foundation of China (32170480,31972866);Youth Innovation Promotion Association,Chinese Academy of Sciences (http://www.yicas.cn);Young Top-notch Talent Cultivation Program of Hubei Province;Wuhan Branch,Supercomputing Center,Chinese Academy of Sciences,China。

摘　　要：Dormancy represents a fascinating adaptive strategy for organisms to survive in unforgiving environments.After a period of dormancy,organisms often exhibit exceptional resilience.This period is typically divided into hibernation and aestivation based on seasonal patterns.However,the mechanisms by which organisms adapt to their environments during dormancy,as well as the potential relationships between different states of dormancy,deserve further exploration.Here,we selected Perccottus glenii and Protopterus annectens as the primary subjects to study hibernation and aestivation,respectively.Based on histological and transcriptomic analysis of multiple organs,we discovered that dormancy involved a coordinated functional response across organs.Enrichment analyses revealed noteworthy disparities between the two dormant species in their responses to extreme temperatures.Notably,similarities in gene expression patterns pertaining to energy metabolism,neural activity,and biosynthesis were noted during hibernation,suggesting a potential correlation between hibernation and aestivation.To further explore the relationship between these two phenomena,we analyzed other dormancy-capable species using data from publicly available databases.This comparative analysis revealed that most orthologous genes involved in metabolism,cell proliferation,and neural function exhibited consistent expression patterns during dormancy,indicating that the observed similarity between hibernation and aestivation may be attributable to convergent evolution.In conclusion,this study enhances our comprehension of the dormancy phenomenon and offers new insights into the molecular mechanisms underpinning vertebrate dormancy.

关 键 词：HIBERNATION AESTIVATION Multi-organs Convergent evolution 

分 类 号：Q953[生物学—动物学]