医用柔性CO_(2)激光传输介质研究进展与展望(特邀)  

Research Progress and Perspective of Clinically Promising Flexible CO_(2) Laser Delivery Mediums(Invited)

作　　者：陶光明 邹郁祁 刘超 任志禾[1,2,3] Tao Guangming;Zou Yuqi;Liu Chao;Ren Zhihe(Wuhan National Laboratory for Optoelectronics,Huazhong University of Science and Technology,Wuhan 430074,Hubei,China;Key Laboratory of Vascular Aging,Ministry of Education,Tongji Hospital Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430074,Hubei,China;State Key Laboratory of Material Processing and Die&Mould Technology,School of Materials Science and Engineering,Huazhong University of Science and Technology,Wuhan 430074,Hubei,China)

机构地区：[1]华中科技大学武汉光电国家研究中心,湖北武汉430074 [2]华中科技大学同济医院血管衰老教育部重点实验室,湖北武汉430074 [3]华中科技大学材料科学与工程学院材料成型与模具技术国家重点实验室,湖北武汉430074

出　　处：《激光与光电子学进展》2024年第1期361-372,共12页Laser & Optoelectronics Progress

基　　金：国家自然科学基金(62175082);华中科技大学交叉研究支持计划(2023JCYJ039)。

摘　　要：中红外激光凭借其非接触、高效率和高精准度的显著优势,广泛应用于病变组织切除、组织整形和肿瘤间质光热疗法等临床外科手术中。在诸多中红外激光中,二氧化碳(CO_(2))激光具备极高消融效率和高精准度的特点,广泛应用于皮肤、耳鼻喉和腹腔等手术中。然而,由于缺乏稳定、高性能的小尺度柔性能量传输介质,CO_(2)激光无法像钬激光、钕激光等近红外激光一样,通过成熟的石英光纤,以微创或无创的方式进入体内,在人体内部自然腔道中进行微创介入操作。目前CO_(2)激光通常通过导光臂、空心波导管等传输介质进行手术,这极大地制约了其优势在微创手术中的充分体现。为使CO_(2)激光更好地服务于临床外科医疗领域,本文总结了现有的医用CO_(2)激光能量传输介质,重点讨论了热拉式多材料光纤技术在CO_(2)激光医疗领域的研究进展,并展望了未来多功能柔性CO_(2)激光消融机器人光纤的发展趋势及应用前景。Mid-infrared (MIR) lasers offer substantial benefits,including non-contact operation,high efficiency,and precision,making them widely utilized in clinical surgical procedures such as lesion tissue removal,tissue plasticity,and tumor interstitial photothermal therapy.Notably,carbon dioxide (CO_2) lasers,among various MIR lasers,are extensively employed in skin,ear,nose,throat,and abdominal surgeries due to their exceptionally high ablation efficiency and precision.However,the lack of stable and high-performance small-scale,flexible laser energy-delivering mediums for CO_(2lasers) restricts their use in minimally invasive or noninvasive procedures,a capability present in mature silica fibers used in holmium,neodymium,and other near-infrared lasers for conducting minimally invasive interventional operations in natural cavities in vivo.Presently,CO_(2) laser procedures typically rely on energy-delivering mediums such as articulated arms and hollow waveguides but this considerably hampers the application of CO_(2) laser in minimally invasive surgeries.To enhance the role of CO_(2) lasers in clinical medicine,we review and summarize existing medical CO_(2) laser energy-delivering mediums,focusing on the advances in thermal-drawn multi-material fiber technology in CO_(2) laser surgery,and explore future development trends and applications of multifunctional flexible CO_(2) laser ablation robotic fibers.

关 键 词：激光医疗 CO_(2)激光 红外光纤 多材料纤维 连续体机器人 

分 类 号：TN214[电子电信—物理电子学] TN219