吸入麻醉药物敏感性的研究进展  

Research progress in sensitivity to inhalation anesthetics

作　　者：任启阳 魏义勇 王海英 REN Qiyang;WEI Yiyong;WANG Haiying(Department of Anesthesiology,Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou 563000,China)

机构地区：[1]遵义医科大学附属医院麻醉科,贵州遵义563000

出　　处：《中国临床研究》2024年第4期493-496,共4页Chinese Journal of Clinical Research

基　　金：国家自然科学基金面上项目(81860062);贵州省科技厅项目(黔科合基础-ZK[2022]一般664);遵义市科技局项目(HZ[2021]46,HZ[2022]229);遵义医科大学博士启动基金项目[院字(2021)3号]。

摘　　要：吸入麻醉药物同时具备镇静、镇痛和肌肉松弛作用,被广泛用于临床麻醉,吸入麻醉药敏感性增加预示着患者不良的术后结局。目前的研究表明,一些基因突变、离子通道或受体、代谢物的变化、线粒体功能等均与人或实验动物对吸入麻醉药的敏感性有关。因此,本文将从基因突变、离子通道或受体、代谢物、线粒体功能等方面,概述吸入麻醉药敏感性机制的研究进展。Inhalation anesthetics have both sedative,analgesic and muscle relaxing effects,and are widely used in clinical practice.Hypersensitivity to inhalation anesthetics predicts poor postoperative outcomes.Current studies have shown that some genetic mutations,ion channels or receptors,changes in metabolites,mitochondrial function are associated with the sensitivity of human or experimental animals to inhalation anesthetics.Therefore,this paper will briefly review the research progress in the mechanism of inhalation anesthetics sensitivity from gene mutation,ion channels or receptors,metabolites,and mitochondrial function.

关 键 词：吸入麻醉药 敏感性 基因突变 离子通道 受体 代谢物 线粒体 

分 类 号：R971.2[医药卫生—药品]