吗啡成瘾的离子通道机制研究进展  

Research progress in ion channel mechanism of morphine addiction

作　　者：陈夏 王勇 魏义勇 CHEN Xia;WANG Yong;WEI Yiyong(School of Anesthesiology,Zunyi Medical University,Zunyi,Guizhou 563099,China)

机构地区：[1]遵义医科大学麻醉医学院,贵州遵义563099 [2]贵州省六盘水市人民医院,贵州六盘水553000 [3]遵义医科大学附属医院麻醉科,贵州遵义563000

出　　处：《中国临床研究》2024年第4期497-500,共4页Chinese Journal of Clinical Research

基　　金：国家自然科学基金面上项目(81860062);贵州省科技厅项目(黔科合基础-ZK[2022]一般664);遵义市科技局项目(HZ[2021]46,HZ[2022]229);遵义医科大学博士启动基金项目[院字(2021)3号]。

摘　　要：吗啡是一种经典的阿片类镇痛药物,常用于治疗慢性痛、癌痛、神经病理性疼痛等。但由于反复使用会产生成瘾,这使得其临床使用受到严重限制。吗啡成瘾已经成为导致某些疾病传播的全球性重大公共卫生问题。然而,目前吗啡成瘾的机制仍然不完全清楚。离子通道是细胞膜上的一种蛋白结构,类似于细胞内外之间的门,可选择性让一些离子进出细胞。目前的研究表明,电压门控、配体门控和机械门控等离子通道均参与了吗啡成瘾的机制。因此本文就吗啡成瘾的上述离子通道机制作一综述。Morphine is a classic opioid analgesic drug commonly used to treat chronic pain,cancer pain,neuropathic pain,etc.But repeated use can be addictive,this makes its clinical use severely limited.Morphine addiction has become a major global public health problem leading to the spread of some diseases.However,the mechanisms of morphine addiction are still not fully understood.An ion channel is a protein structure on the cell membrane,similar to a gate between inside and outside of the cell,that selectively allows some ions to enter and exit the cell.Current research shows that voltage-gated,ligand-gated and mechanically gated ion channels are all involved in the mechanism of morphine addiction.Therefore,this paper reviews the mechanism of voltage-gated,ligand-gated and mechanically gated ion channel for morphine addiction.

关 键 词：吗啡耐受 吗啡成瘾 离子通道 电压门控 配体门控 机械门控 

分 类 号：R971.2[医药卫生—药品]