中药有效成分干预运动性骨骼肌损伤的作用机制研究进展  

Research progress on the mechanism of effective components of traditional Chinese medicine in the intervention of exercise-induced skeletal muscle damage

作　　者：张碧峰 刘建军 安文博 元宝华 刘晓婷 ZHANG Bifeng;LIU Jianjun;AN Wenbo;YUAN Baohua;LIU Xiaoting(Department of Orthopaedics,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China;Clinical College of Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学附属医院骨科,兰州730000 [2]甘肃中医药大学中医临床学院,兰州730000

出　　处：《数理医药学杂志》2024年第4期303-312,共10页Journal of Mathematical Medicine

摘　　要：运动性骨骼肌损伤(exercise-induced skeletal muscle damage,EIMD)属于运动医学科高发病率疾患之一,对患者日常生活和工作有较大影响。研究表明,中药有效成分包括皂苷类、多酚类、多糖类、黄酮类及其他异硫氰酸酯类、苯丙素类、羧酸类等活性物质可抑制实验动物及临床观察患者的炎症反应、氧化应激和线粒体自噬,促进肌卫星细胞增殖分化,调控核红细胞2相关因子2(nuclear factor erythroid-2 related factor 2,Nrf2)/血红素氧合酶1(heme oxygenase-1,HO-1)、磷脂酰肌醇-3激酶(phosphatidylinositol 3-kinase,PI3K)/蛋白激酶B(protein kinase B,PKB/Akt)、磷酸化38丝裂原活化蛋白激酶(phosphorylation mitogen 38-activated protein kinase,p38 MAPK)等相关信号通路,促使受损的骨骼肌组织修复并加速修复进程。中药历史悠久,具有副作用小、多治疗靶点及价格实惠等优势,在EIMD的治疗中具有极大的潜力和应用前景。本文就近年来关于中药有效成分治疗EIMD的作用机制做一综述,以期为EIMD治疗和康复提供参考和依据。Exercise-induced skeletal muscle damage(EIMD)is one of the diseases with high incidence in sports medicine,which has a great impact on the daily life and work of patients.Studies have shown that the effective components of traditional Chinese medicine,including saponins,polyphenols,polysaccharides,flavonoids and other active substances,such as isothiocyanates,phenylpropanoids and carboxylic acids,can inhibit inflammation,oxidative stress and mitochondrial autophagy in experimental animals and patients for clinical observation,promote the proliferation and differentiation of muscle satellite cells,regulate nuclear factor erythroid-2 related factor 2(Nrf2)/heme-oxygenase-1(HO-1),phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/Akt), phosphorylation mitogen 38-activated protein kinase (p38 MAPK) and other related signaling pathways, and promote the repair of damaged skeletal muscle tissue and speed up the repair process. Traditional Chinese medicine has the characteristics of long history, few side effects, multiple treatment targets and affordable price, so it has great potential and bright application prospect in the treatment of EIMD. This article reviews the mechanism of effective components of traditional Chinese medicine in the treatment of EIMD in recent years, in order to provide reference and basis for the treatment and rehabilitation of EIMD.

关 键 词：运动性骨骼肌损伤 中药有效成分 氧化应激 线粒体 信号通路 

分 类 号：R285[医药卫生—中药学]