补肾增液汤加减联合左卡尼汀对弱精子症患者精液参数及IVF-ET相关指标的影响  

Effects of the dialectical Bushenzengye decoction combined with L-carnitine for treating patients with asthenospermia on their semen parameters and the related indexes of their in vitro fertilization and embryo transplantation

作　　者：马秀丽[1] 贾蓉[1] MA Xiuli;JIA Rong(Chang Zhou Wujin Hospiral ofTraditional Chinese Medicine,Chang zhou,Jiangsu Province,213161)

机构地区：[1]江苏省常州市武进中医医院,213161

出　　处：《中国计划生育学杂志》2024年第4期778-783,共6页Chinese Journal of Family Planning

摘　　要：目的:探究补肾增液汤辩证加减联合左卡尼汀对弱精子症患者精液参数、体外受精-胚胎移植(IVF-ET)指标的影响。方法:收集2020年1月-2022年1月在本院中心行IVF周期治疗弱精子症94例临床资料,按治疗方式分为对照组(n=41例,左卡尼汀治疗)与联合组(n=53例,补肾增液汤辩证加减联合左卡尼汀治疗),疗程12周,比较两组治疗效果、治疗前后精液质量分析、性功能及IVF周期相关指标。结果:治疗后,联合组精液量(3.71±0.75ml)、精子浓度(30.05±5.75)10^(6)个/ml、精子存活率(58.63±10.14)%、a+b级精子率(66.65±10.45)%均高于对照组[(3.08±0.89ml)、(27.63±5.07)10^(6)个/ml、(53.17±8.45)%、(60.74±8.71)%];勃起信心(3.65±0.46分)、勃起时间(3.89±0.35分)、勃起维持时间(3.63±0.45分)、性交困难(4.35±0.25分)、性满足(4.05±0.21分)及总分(19.57±1.72分)均高于对照组(3.37±0.31分、3.41±0.29分、3.23±0.23分、4.11±0.16分、3.33±0.15分、17.45±1.14分);受精率(82.8±5.1)%、优质胚胎率(56.9±10.3)%、可移植胚胎数目(2.4±0.5个)及临床妊娠率(60.0%)均高于对照组[(81.0±3.7)%、(48.5±8.0)%、1.5±0.5个、37.5%];治疗总有效率(90.6%)高于对照组(73.2%)(均P<0.05)。结论:补肾增液汤辩证加减联合左卡尼汀可提高弱精子症患者精液质量,改善患者性功能,有利于改善IVF-ET周期指标,提高IVF-ET成功率。Objective:To explore the effects of the dialectical Bushenzengye decoction combined with L-carnitine for treating patients with asthenospermia on their semen parameters and the related indexes of their in vitro fertilization.Methods:94 patients with asthenospermia who wanted the treatment of IVF cycle were selected and were divided into control group(41 cases with the treatment of L-carnitine for 12 weeks)and the study group(53 cases with the treatment of the dialectical Bushenzengye decoction combined with L-carnitine for 12 weeks)according to the different treatment methods from January 2020 to January 2022.The treatment effect,the semen quality analysis before and after treatment,the sexual function and IVF cycle related indexes of the patients were compared between the two groups.Results:The semen volume(3.71±0.75ml),the sperm concentration(30.05±5.7510^(6)cells/ml),the sperm survival rate(58.63±10.14%),the rate of the a+b level sperm(66.65±10.45%)of the patients in the study group after treatment were significantly higher than those(3.08±0.89ml,27.63±5.0710^(6)cells/ml,53.17±8.45%and 60.74±8.71%)of the patients in the control group.The scores of the erection confidence(3.65±0.46 points),the erection time(3.89±0.35 points),the erection maintenance time(3.63±0.45 points),the difficulty of sexual intercourse(4.35±0.25 points),the sexual satisfaction(4.05±0.21 points)and the total score(19.57±1.72 points)of the patients in the study group were significantly higher than those(3.37±0.31 points,3.41±0.29 points,3.23±0.23 points,4.11±0.16 points,3.33±0.15 points and 17.45±1.14 points)of the patients in the control group.The fertilization rate(82.8±5.1%),the high-quality embryo rate(56.9±10.3%),the number of transferrable embryos(2.4±0.5 pieces)and the clinical pregnancy rate(60.0%)of the patients in the study group were significantly higher than those(81.0±3.7%,48.5±8.0%,1.5±0.5 pieces and 37.5%)of the patients in the control group.The total effective rate(90.6%)of the patients in the study

关 键 词：弱精子症 左卡尼汀 补肾增液汤 精液质量 性功能 体外受精-胚胎移植 

分 类 号：R698.2[医药卫生—泌尿科学]