早孕先兆流产患者血FVⅢ活性、PAI-1水平及其对保胎结局的影响  

Coagulation factor VIII activity and plasminogen activator inhibitor-1 level of pregnant women with threatened miscarriage during the first trimester of pregnancy and their influence on the tocolytic outcomes

作　　者：高承香 韩月欣 张凌云 GAO Chengxiang;HAN Yuexin;ZHANG Lingyun(Qingdao Jiaozhou Central Hospital,Jiaozhou,Shandong Province,266300)

机构地区：[1]青岛市胶州中心医院,266300

出　　处：《中国计划生育学杂志》2024年第4期844-847,共4页Chinese Journal of Family Planning

基　　金：2022-2024年青岛市市级临床重点专科妇产专科资助。

摘　　要：目的:探究凝血因子Ⅲ(FVⅢ)活性、纤溶酶原激活物抑制剂-1(PAI-1)对早孕先兆流产保胎结局的预测价值。方法:回顾性分析本院于2020年1月-2022年12月收治的345例早孕先兆流产患者临床资料,根据保胎结局分为保胎失败组124例、成功组221例,检测两组血FVⅢ活性、PAI-1水平,超声检测子宫内膜厚度(EST),血清β-人绒毛膜促性腺激素(β-hCG)、雌二醇(E_(2))、孕酮(P),采用多因素logistic回归分析早孕先兆流产保胎成功影响因素。结果:失败组FVⅢ活性(168.31±25.84)%、PAI-1(54.39±6.05μg/l)均高于成功组(138.64±24.61)%、(49.31±5.87μg/l),EST(10.06±3.26 mm)、β-hCG(1763.86±706.77 U/L)、E_(2)(1051.16±369.57 poml/L)、P(32.96±15.72 noml/L)水平均低于成功组(12.55±1.91 mm、3299.46±1831.59 U/L、3571.36±1126.29 poml/L、64.38±17.24 noml/L)(均P<0.05)。多因素logistic回归分析显示,FVⅢ活性升高,β-hCG、E_(2)、P水平降低为影响早孕先兆流产保胎成功的危险因素(P<0.05),而PAI-1为保胎成功非危险因素。结论:FVⅢ活性升高影响保胎成功,临床可予以参考,减少盲目保胎带来的风险。Objective:To investigate the predictive value of the coagulation factor VⅢ(FVIID)activity and plasminogen activator inhibitor 1(PAI-1)level of pregnant women with threatened miscarriage during the first trimester of pregnancy for their tocolytic outcomes.Methods:The clinical data of 345 pregnant with threatened miscarriage during the first trimester of pregnancy from January 2020 to December 2022 were analyzed retrospectively.According to the tocolytic outcomes,these women were divided into group A(124 cases with the failure of tocolytic outcomes)and group B(221 cases with the successful tocolytic outcomes).The FVIII activity and the levels PAI-1,beta human chorionic gonadotropin(β-hCG),serum estradiol(E_(2))and progesterone(P)of the women in the two groups were detected.The endometrial thickness(ET)of the women in the two groups was examined by ultrasound.Multivariate logistic regression analysis was conducted to identify the influencing factors of the successful tocolytic outcomes of the pregnant women with threatened miscarriage during the first trimester of pregnancy,Results:The FVIII activity(168.31±25.84%)and the PAI-1 level(54.39±6.05μg/l)of the women in group A were significantly higher than those(138.64±24.61%and 49.31±5.87μg/l)of the women in group B.The ET value(10.06±3.26 mm)and the levels of β-hCG(1763.86±706.77U/L),E_(2)(1051.16±369.57 poml/L)and P(32.96±15.72 noml/L)of the women in group A were significantly lower than those(12.55±1.91 mm,3299.46±1831.59U/L,3571.36±1126.29poml/L and 64.38±17.24 noml/L)of the women in group B(all P<0.05).Multivariate logistic regression analysis showed that the increase of the FVIII activity and the decrease of the levels of β-hCG,E_(2)and P were risk factors for the successful tocolytic outcomes of the pregnant women with threatened miscarriage during the first trimester of pregnancy(P<0.05),while the PAI-1 level was not a risk factor for their successful tocolytic outcomes.Conclusion:The increase of FVIII activity of the pregnant women with thre

关 键 词：早孕 先兆流产 保胎 凝血因子Ⅲ 纤溶酶原激活物抑制剂-1 影响因素 

分 类 号：R714.21[医药卫生—妇产科学]