米非司酮不同给药方案对终止妊娠后阴道出血时间、子宫内膜容受性的影响  

Effects of the different administration methods and the different doses of mifepristone for treating patients with termination of pregnancy on their vaginal bleeding time and endometrial receptivity

作　　者：姜淑丽 张欢欢 JIANG Shuli;ZHANG Huanhuan(Hebi Hospital of Traditional Chinese Medicine,Hebi,Henan Province,458000)

机构地区：[1]河南省鹤壁市中医院,458000

出　　处：《中国计划生育学杂志》2024年第4期848-852,共5页Chinese Journal of Family Planning

摘　　要：目的:探究米非司酮不同给药方案对终止妊娠后阴道出血时间、子宫内膜容受性的影响。方法:回顾性分析2021年5月-2023年5月本院收治的96例药物终止妊娠临床资料,依据米非司酮使用情况分为单次组(n=30)、常规组(n=34)、长期组(n=32),分别予以米非司酮100mg顿服、150mg分2d口服、150mg分2.5d口服。比较3组术后阴道出血情况,后术3个月子宫内膜容受性指标子宫内膜厚度、阻力指数(RI)、搏动指数(PI)、卵巢功能指标雌二醇(E2)、孕酮(P)、抗苗勒氏管激素(AMH)差异,术后并发症、用药不良反应。结果:单次组术中阴道出血量(23.2±3.6 ml)、阴道出血时间(4.1±0.9d)、术后阴道出血量(57.7±8.4 ml)、月经复潮时间(25.7±2.4d)均低于常规组(27.0±4.1d、4.7±1.1 ml、62.5±9.6d、28.5±2.7 ml)、长期组(27.6±4.1 ml、5.1±1.1d、65.3±10.0 ml、29.6±3.0d)(均P<0.05),常规组与长期组上述指标均无差异(P>0.05);终止妊娠3个月后,单次组子宫内膜厚度(8.35±0.76mm)高于常规组(7.84±0.81mm)、长期组(7.69±0.88mm),RI低于长期组,PI均低于常规组、长期组(均P<0.05);3组E2、AMH、P水平及术后并发症均无差异(P>0.05);恶心呕吐、胃痛发生率单次组(3.3%、10.0%)、常规组(2.9%、8.8%)均低于长期组(21.9%、34.4%)(均P<0.05),3组腹泻、头晕、乏力发生率未见差异(P>0.05)。结论:单次大剂量米非司酮有助于终止妊娠,延长用药时间可能导致用药不良反应增多。Objective:To explore the effects of the different administration methods and the different doses of mifepristone for treating patients with termination of pregnancy on their vaginal bleeding time and endometrial receptivity.Methods:The clinical data of 96 patients with termination of pregnancy admitted to the hospital from May 2021 to May 2023 were analyzed retrospectively.According to the different administration of mifepristone,the patients were divided into three groups,which included that 30 patients in group A were given oral mifepristone 200 mg once,34 patients in group B were given oral mifepristone 150 mg administration in 2 days and 32 patients in group C were given oral mifepristone administration in 2.5 days.The postoperative vaginal bleeding situation,the values of the endometrial receptivity indicators in the 3rd month after abortion,such as endometrial thickness,resistance index(RI)and pulsatility index(PI),and the levels of ovarian function indicators,such as estradiol(E_(2)),progesterone(P)and anti-Mullerian hormone(AMH),the rates of the postoperative complications and drug adverse reactions of the patients were compared among the three groups.Results:The intraoperative vaginal bleeding volume(23.2±3.6 ml),the vaginal bleeding time(4.1±0.9d),the postoperative vaginal bleeding volume(57.7±8.4ml),the menstrual recovery time(25.7±2.4d)of the patients in group A were significantly lower than those(27.0±4.1d,4.7±1.1 ml,62.5±9.6d and 28.5±2.7 ml)of the patients in group Band those(27.6±4.1 ml,5.1±1.1d,65.3±10.0 ml and 29.6±3.0d)of the patients in group C(all P<0.05),but which of the patients had no significant differences between group Band group C(P>0.05).In the 3rd month after termination of pregnancy,the endometrial thickness(8.35±0.76mm)of the patients in group A was significantly higher than that(7.84±0.81mm)of the patients in group B and that(7.69±0.88 mm)of the patients in group C,the RI value of the patients in group A was significantly lower than that of the patients in group C,a

关 键 词：终止妊娠 米非司酮 不同剂量 不同给药时间 阴道出血 子宫内膜容受性 卵巢功能 不良反应 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]