子宫内膜恶性病变组织中E-cadherin、VEGF表达及与生存关系  

Correlation between the expressions of E-cadherin,vascular endothelial growth factor and vascular endothelial growth factor in the endometrial lesions of patients and their survival situation

作　　者：法良玲 史航 黄臻 FA Liangling;SHI Hang;HUANG Zhen(Jiaozhou Central Hospital,Qingdao,Shandong Province,266300)

机构地区：[1]青岛市胶州中心医院,266300

出　　处：《中国计划生育学杂志》2024年第4期917-922,共6页Chinese Journal of Family Planning

摘　　要：目的:探究E-钙黏蛋白(E-cadherin)、血管内皮生长因子(VEGF)在子宫内膜恶性病变中的表达及与预后生存关系。方法:病例源于2018年1月-2023年1月本院收治的607例子宫内膜病变患者临床资料,依据术后病理结果分为良性病变组457例、恶性病变组150例,依据恶性病变组随访结果分为存活组和死亡组。免疫组化检测子宫内膜病变组织中E-cadherin、VEGF蛋白表达,分析其与恶性病变患者预后生存关系。结果:恶性病变组E-cadherin阳性率(30.0%)低于良性病变组(78.8%),VEGF阳性率(68.0%)高于良性病变组(29.8%)(均P<0.05)。随访10~59个月(中位数29个月),恶性病变组150例中死亡36例(24.0%),总生存时间E-cadherin阳性患者长于E-cadherin阴性患者(Log rank χ^(2)=8.033),VEGF阳性患者短于VEGF阴性患者(Log rank χ^(2)=8.343)。与存活组比较,死亡组FIGO分期为Ⅲ~Ⅳ期、分化程度为低分化、浸润深度≥1/2、肿瘤累及子宫下段、淋巴结转移占比、E-cadherin阴性表达率、VEGF阳性表达率均更高,E-cadherin阴性表达、VEGF阳性表达是子宫内膜恶性病变患者预后的独立危险因素(P<0.05)。E-cadherin阴性表达联合VEGF阳性表达鉴别子宫内膜良恶性病变的曲线下面积0.848、敏感性86.4%。结论:E-cadherin阴性表达、VEGF阳性表达与子宫内膜恶性病变的发生发展有关,联合检测对恶性病变预后有一定评估价值。Objective:To investigate between the expressions of E-cadherin and vascular endothelial growth factor(VEGF)in the endometrial lesions of patients and their survival situation.Methods:The clinical data of 607 patients with endometrial lesions admitted to the hospital from January 2018 to January 2023 were selected in this study.Based on the postoperative pathological results,these patients were divided into group A(patients with benign endometrial lesion)and group B(patients with malignant endometrial lesion).According to the follow-up results,the patients in group B were divided into group B1(patients with survival)and group B2(patients with death).The expressions of E-cadherin and VEGF in the endometrial lesions of the patients in these groups were detected by immunohistochemistry,and the correlation between which of the patients in group B and their survival prognosis was analyzed.Results:The positive rate of E-cadherin(30.0%)of the patients in group B was significantly lower than that(78.8%)of the patients in group A,and the positive rate of VEGF(68.0%)of the patients in group B was significantly higher than that(29.8%)of the patients in group A(all P<0.05).During the follow-up of 10-59 months(median of 29 months)after surgery,36(24.0%)patients in group B of 150 patients had died.The overall survival time of the patients with positive E-cadherin was significantly longer than that of the patients with negative E-cadherin(Log rank χ^(2)=8.033).The overall survival time of the patients with positive VEGF were significantly shorter than that of the patients with negative VEGF(Log rank χ^(2)=8.343).The proportions of FIGO stage Ⅲ-Ⅳ,the tumor low differentiation,the tumor invasion depth≥1/2,the tumor invasion of the lower uterine segment,the lymph node metastasis,the negative expression of E-cadherin and the positive expression of VEGF of the patients in group B2 were significantly higher than those of the patients in group B1.The negative expression of E-cadherin and the positive expression of VEGF of the p

关 键 词：子宫内膜病变 E-钙黏附素 血管内皮生长因子 鉴别诊断 生存预后 

分 类 号：R711.74[医药卫生—妇产科学]