GDM发病影响因素及与不良妊娠结局关系  

Influence factors of the onset of gestational diabetes mellitus of pregnant women and their correlation with the adverse pregnancy outcomes

作　　者：郑琍 汤琳 孙待飞 朱彩丹 ZHENG Li;TANG Lin;SUN Daifei;ZHU Caidan(Affiliated to Ningbo University Women and Children's Hospital,Ningbo,Zhejiang Province,315000)

机构地区：[1]宁波大学附属妇女儿童医院,315000

出　　处：《中国计划生育学杂志》2024年第4期938-942,共5页Chinese Journal of Family Planning

基　　金：2024年度浙江省医药卫生科技计划项目(2024KY1574)。

摘　　要：目的:探究妊娠期糖尿病(GDM)发病因素以及对妊娠结局的影响。方法:选取本院2021年2月-2023年2月产前检查孕妇临床资料,GDM孕妇、健康孕妇各120例分别纳入病例组、对照组,对比两组临床因素与实验室指标,多因素logistic回归分析GDM发生的影响因素,对比两组不良妊娠结局。结果:病例组年龄≥35岁、孕期体质指数(BMI)≥28kg/m^(2)、孕期体重增长≥8kg比例均高于对照组,血丙二醛(MDA)、三酰甘油(TG)、总胆固醇(TC)水平均高于对照组,超氧化物歧化酶(SOD)水平低于对照组(均P<0.05);logistic回归分析显示,年龄≥35岁、孕期BMI≥28kg/m^(2)、孕期体重增长≥8kg,以及MDA、TG、TC异常升高均为GDM发生的影响因素,SOD升高是GDM的保护因素。病例组巨大儿、胎膜早破、剖宫产、新生儿黄疸、早产发生率均高于对照组(P<0.05)。结论:GDM发生与孕妇年龄、孕期BMI、孕期体重增长、MDA、TG、TC、SOD等异常有关,且GDM会增加不良妊娠结局发生风险。Objective:To explore the influencing factors of the onset of gestational diabetes mellitus(GDM)of pregnant women,and to study their correlation with the adverse pregnancy outcomes of the women.Methods:The clinical data of 120 pregnant women with GDM(in study group)and 120 healthy pregnant women(in control group)that had been accepted the antenatal examinations in hospital from February 2021 to February 2023 were selected in this study.The clinical factors and the laboratory indicators of the women were compared between the two groups.The influencing factors of the GDM occurrence of the women were analyzed by multivariate logistic regression analysis.The rate of the adverse pregnancy outcomes of the women was compared between the two groups.Results:The proportions of the age≥35 years old,the body mass index(BMI)during pregnancy≥28kg/m^(2),and the weight gain during pregnancy≥8kg,and the levels of malondialdehyde(MDA),triglyceride(TG),and total cholesterol(TC)of the women in the study group were significantly higher than those of the women in the control group,but the level of superoxide dis-mutase(SOD)of the women in the study group was significantly lower(all P<0.05).Logisticregression analysis showed that the age≥35 years old,the gestational BMI≥28kg/m^(2),the gestational weight gain≥8kg,the abnormal increase of the levels of MDA,TG and TC of the women were the influencing factors of their GDM occurrence,and the increase of the SOD level of the women was the protective factor of their GDM occurrence.The incidences of the macrosomia,premature rupture of membranes,cesarean section,neonatal jaundice and premature delivery of the women in the study group were significantly higher than those of the women in the control group(P<0.05).Conclusion:The GDM occurrence of the pregnant women is associated with their age,their gestational BMI and weight gain,and their abnormal levels of MDA,TG,TC,and SOD.The GDM occurrence of the pregnant women can increase the risk of their adverse pregnancy outcomes.

关 键 词：妊娠期糖尿病 影响因素 不良妊娠结局 

分 类 号：R714.256[医药卫生—妇产科学]